Results 221 to 230 of about 24,238 (294)

Regulation of Cajal bodies: Unexpected connection to 60S ribosomes. [PDF]

J Cell Biol
Courvan EMC, Parker RR.
europepmc   +1 more source

Cucumber green mottle mosaic virus: A persistent seed‐borne threat to cucurbits

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Cucumber green mottle mosaic virus (CGMMV) is a highly stable, seed‐borne tobamovirus that threatens global cucurbit production. Its efficient mechanical and seed transmission, long‐term environmental persistence, and the spread of Clade II CGMMV isolates drive its rapid dissemination and cause severe yield losses.
Esperanza Gea‐Caballero, Miguel A. Aranda   +1 more
wiley   +1 more source

Protocol for non-invasive delivery of CRISPR RNPs via virus-like particles for mouse model generation. [PDF]

STAR Protoc
Yoon DE, Yang J, Jeong TY, Park J, Lee H, Seong JK, Kim K.   +6 more
europepmc   +1 more source

Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice

Andrology, Volume 14, Issue 5, Page 1240-1248, July 2026.
ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang, Anh Hoang Pham, Mengjiao Luo, Masahito Ikawa, Haruhiko Miyata   +4 more
wiley   +1 more source

Establishment of Efficient CRISPR-Cas9 PEG-Mediated DNA-Free Genome Editing Through Ribonucleoproteins Method in Hexaploid Sweetpotato (<i>Ipomoea batatas</i> L. (Lam)) Targeting the <i>EIF</i>-<i>4E</i> Genes. [PDF]

Plants (Basel)
Brown APA, Egnin M, Bukari F, Ritte IP, Bernard GC.   +4 more
europepmc   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Pharmacological Activation of NRF2 by Omaveloxolone Upregulates NRF2‐Target Proteins in SMA Type I Human Fibroblasts

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
SMA type I patient‐derived fibroblasts exhibit reduced basal NRF2 pathway output, reflected by decreased NQO1, xCT, and PGC1α. Pharmacological NRF2 activation with omaveloxolone (OMAV) increases cell viability and induces NRF2 target proteins in both control and SMA fibroblasts.
Sofia Vrettou, Sebastian Zetzsche, Brunhilde Wirth   +2 more
wiley   +1 more source

Rethinking CRISPR delivery for liver-targeted gene editing: The case for spatially fractionated intra-arterial approaches. [PDF]

Mol Ther Nucleic Acids
Salemdawod A, Walczak P, Janowski M.
europepmc   +1 more source

Encapsulin‐Protected Immunotherapeutic Complexes: Bacteria‐Derived Nanoparticles for mRNA Delivery to Eukaryotic Cells

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Here, we introduce a biological, self‐assembling supramolecular nanoparticle designed to encapsulate eukaryotic‐expressible mRNA within an encapsulin shell via an encapsulin‐RNA adaptor peptide (ERAP). This process occurs in bacteria, and the resulting complex can deliver its mRNA into eukaryotic cells, where it is expressed.
Carlos Francisco Coffeen, Maribel Cayetano‐Cruz, Damaris Ilhuicatzi‐Alvarado, Carmen Méndez, Leticia Moreno‐Fierros, Ismael Bustos‐Jaimes   +5 more
wiley   +1 more source

Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics. [PDF]

J Am Chem Soc
Tennakoon SC, Giese SB, Shaw JB.
europepmc   +1 more source