Results 31 to 40 of about 57,913 (382)

Biogenesis of telomerase ribonucleoproteins [PDF]

RNA, 2012
Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract the loss of end sequence inherent in conventional DNA replication. Catalytic activity for repeat synthesis results from the cooperation of the telomerase reverse transcriptase protein (TERT) and the template-containing telomerase RNA (TER).
Emily D. Egan, Kathleen Collins
openaire   +2 more sources

Morphology of influenza B/Lee/40 determined by cryo-electron microscopy. [PDF]

PLoS ONE, 2014
Cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza B/Lee/40. Algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of
Garrett Katz, Younes Benkarroum, Hui Wei, William J Rice, Doris Bucher, Alexandra Alimova, Al Katz, Joanna Klukowska, Gabor T Herman, Paul Gottlieb   +9 more
doaj   +1 more source

Genome editing in potato via CRISPR-Cas9 ribonucleoprotein delivery [PDF]

, 2018
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein-9 (CRISPR-Cas9) can be used as an efficient tool for genome editing in potato (Solanum tuberosum).
Andersson, Andersson, Cho, Clasen, Eriksson, Gorbunova, Hartung, Jinek, Jones, Kim, Kuipers, Kuipers, Larkin, Liang, Muthoni, Nelson, Sawai, Shepard, Svitashev, Visser, Woo, Xu, Zhang   +22 more
core   +1 more source

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Nature Communications, 2021
GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour, Deepa S. Rajan, Tyler R. Fortuna, Eric N. Anderson, Caroline Ward, Youngha Lee, Sangmoon Lee, Yong Beom Shin, Jong-Hee Chae, Murim Choi, Karine Siquier, Vincent Cantagrel, Jeanne Amiel, Elliot S. Stolerman, Sarah S. Barnett, Margot A. Cousin, Diana Castro, Kimberly McDonald, Brian Kirmse, Andrea H. Nemeth, Dhivyaa Rajasundaram, A. Micheil Innes, Danielle Lynch, Patrick Frosk, Abigail Collins, Melissa Gibbons, Michele Yang, Isabelle Desguerre, Nathalie Boddaert, Cyril Gitiaux, Siri Lynne Rydning, Kaja K. Selmer, Roser Urreizti, Alberto Garcia-Oguiza, Andrés Nascimento Osorio, Edgard Verdura, Aurora Pujol, Hannah R. McCurry, John E. Landers, Sameer Agnihotri, E. Corina Andriescu, Shade B. Moody, Chanika Phornphutkul, Maria J. Guillen Sacoto, Amber Begtrup, Henry Houlden, Janbernd Kirschner, David Schorling, Sabine Rudnik-Schöneborn, Tim M. Strom, Steffen Leiz, Kali Juliette, Randal Richardson, Ying Yang, Yuehua Zhang, Minghui Wang, Jia Wang, Xiaodong Wang, Konrad Platzer, Sandra Donkervoort, Carsten G. Bönnemann, Matias Wagner, Mahmoud Y. Issa, Hasnaa M. Elbendary, Valentina Stanley, Reza Maroofian, Joseph G. Gleeson, Maha S. Zaki, Jan Senderek, Udai Bhan Pandey   +69 more
doaj   +1 more source

Preparation of Cas9 Ribonucleoproteins for Genome Editing

Bio-Protocol, 2022
Genome editing by the delivery of pre-assembled Cas9 ribonucleoproteins (Cas9 RNP) is an increasingly popular approach for cell types that are difficult to manipulate genetically by the conventional plasmid and viral methods.
SW Lin, Viet Nguyen, Steven Lin
doaj   +1 more source

PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle [PDF]

, 1989
The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein.
Abelson, John N., Banroques, Josette
core   +1 more source

Vesicular transport of a ribonucleoprotein to mitochondria [PDF]

Biology Open, 2014
ABSTRACT Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria. Through RNA interference, it was shown that mito-targeting of the ribonucleoprotein (RNP) was dependent on ...
Samit Adhya, Biraj Mahato, Joyita Mukherjee   +2 more
openaire   +4 more sources

Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases

Molecular Neurobiology, 2020
Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational ...
Yi-Hua Low, Y. Asi, Sandrine C. Foti, T. Lashley   +3 more
semanticscholar   +1 more source

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

Genome Research, 2014
RNA-guided engineered nucleases (RGENs) derived from the prokaryotic adaptive immune system known as CRISPR (clustered, regularly interspaced, short palindromic repeat)/Cas (CRISPR-associated) enable genome editing in human cell lines, animals, and ...
Sojung Kim, Daesik Kim, S. Cho, Jungeun Kim, Jin-Soo Kim   +4 more
semanticscholar   +1 more source

The Nucleolus and the Four Ribonucleoproteins of Translation [PDF]

The Journal of Cell Biology, 2000
The classical view of the nucleolus as solely committed to ribosome biosynthesis has been modified by recent studies pointing to additional roles for this nuclear domain. These newly recognized features include the nucleolar presence of several nonribosomal RNAs transcribed by RNA polymerase III ...
Pederson, Thoru, Politz, Joan C. Ritland
openaire   +4 more sources