PLoS Pathogens, 2012 Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects.
Jamie J Arnold +18 more
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Effects of Rosemary Extract on C2C12 Myoblast Differentiation and 5-Aminoimidazole-4-carboxamide Ribonucleoside (AICAR)-Induced Muscle Cell Atrophy [PDF]
Applied Sciences, 2023 Sarcopenia is an aging-related disease that involves the gradual loss of muscle mass and function. However, no suitable therapeutic drugs are currently available. Accordingly, the purpose of the present study was to evaluate the effectiveness of rosemary
Jun Ho Lee +6 more
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The Consequence of the Presence of Ribonucleotide for ds-DNA’s Electronic Properties: Preliminary Theoretical Studies [PDF]
CellsThe genome is continuously exposed to different harmful factors whose activity causes different types of lesions. On the other hand, during the DNA replication process, a ribonucleoside (rN) can be inserted more frequently than the occurrence of DNA ...
Boleslaw T. Karwowski
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Mechanochemical Reactivity of Ribonucleosides Mediated by Inorganic Species: Implications for Extraterrestrial Organic Matter Interpretation [PDF]
Applied SciencesMetal species and carbonate are often found as minerals in extraterrestrial rocky bodies. Based on this, the mechanochemical-induced degradation of canonical purine and pyrimidine ribonucleosides into their corresponding nucleobases mediated by some of ...
Gustavo P. Maia +7 more
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Pyrimidine Biosynthesis and Ribonucleoside Metabolism in Species of Pseudomonas
Fermentation, 2023 Pyrimidine biosynthesis and ribonucleoside metabolism in species of Pseudomonas was the focus of this review, in relation to their current taxonomic assignments in different homology groups.
Thomas P. West
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Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses
Biomolecules, 2023 Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants.
Leonid A. Shaposhnikov +3 more
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Journal of Analytical Science and Technology, 2020 With the ability to differentiate different molecular sizes, ion mobility spectrometry (IMS) has great potentials in the analysis of isomeric compounds. However, due to the lack of sensitivity and resolution, IMS has not been commonly used.
Hongzhou Wang +2 more
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Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation
Scientific Reports, 2023 SARS-CoV-2 causes the severe respiratory disease COVID-19. Remdesivir (RDV) was the first fast-tracked FDA approved treatment drug for COVID-19. RDV acts as an antiviral ribonucleoside (adenosine) analogue that becomes active once it accumulates ...
Nicole DeFoor +9 more
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RRM2 expression in different molecular subtypes of breast cancer and its prognostic significance
Diagnostic Pathology, 2022 Background Breast cancer is one of the most common types of cancer. Ribonucleotide reductase (RNR) is a heterodimeric tetramer consisting of two Ribonucleoside-diphosphate reductase large subunits (RRM1) and two Ribonucleoside-diphosphate reductase small
Manar Ahmed Abdel-Rahman +2 more
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Redox Biology, 2016 Complex metabolism is thought to occur exclusively in the crowded intracellular environment. Here we report that diluted enzymes from lysed human leukocytes produce extracellular energy.
John B. Hibbs Jr. +2 more
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