Results 11 to 20 of about 22,086 (209)
Partition Chromatography on Starch of Ribonucleosides [PDF]
Nature, 1948 DURING work on ribonucleic acid turnover with nitrogen-15 in this Department, we found it necessary to isolate the different nitrogen-containing substances from small amounts of ribonucleic acid. It was thought that partition chromatography on starch as introduced by Elsden and Synge1 might give a possible solution to our problem. Vischer and Chargaff2
Peter Reichard
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Naturally occurring modified ribonucleosides [PDF]
WIREs RNA, 2020 AbstractThe chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life.
Phillip J. McCown +7 more
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Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
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Ribonucleosides of Allopurinol and Oxoallopurinol
Journal of Biological Chemistry, 1967 Thomas A. Krenitsky +3 more
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Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractProtecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection and oligonucleotide synthesis.
Radhakrishnan P. Iyer
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Nature Communications, 2020 Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and ...
Sathya Balachander +14 more
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Regulation of translation by methylation multiplicity of 18S rRNA
Cell Reports, 2021 Summary: N6-methyladenosine (m6A) is a conserved ribonucleoside modification that regulates many facets of RNA metabolism. Using quantitative mass spectrometry, we find that the universally conserved tandem adenosines at the 3′ end of 18S rRNA, thought ...
Kuanqing Liu +6 more
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Molecules, 2019 Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been reported, the development of highly efficient enzymes for industrial applications is still in high ...
Gaofei Liu +4 more
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Practical Silyl Protection of Ribonucleosides [PDF]
Organic Letters, 2013 Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural ...
Thomas P, Blaisdell +4 more
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Molecules, 2011 There are more than 100 different ribonucleoside structures incorporated as post-transcriptional modifications, mainly in tRNA and rRNA of both prokaryotes and eukaryotes, and emerging evidence suggests that these modifications function as a system in ...
Peter C. Dedon +8 more
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