Results 11 to 20 of about 26,264 (280)
Naturally occurring modified ribonucleosides [PDF]
WIREs RNA, 2020 AbstractThe chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life.
Phillip J. McCown +7 more
openaire +3 more sources
Deoxyribo‐ and Ribonucleoside H‐Phosphonates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2001 AbstractMost methods for preparing H‐phosphonate monoesters suffer from variable yields and are often incompatible with common protecting groups used in oligonucleotide synthesis. This unit describes four procedures that consistently give high yields of the desired products.
Jacek Stawiński, Roger Strömberg
openalex +5 more sources
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
openaire +6 more sources
An Intestinal Phosphorylase for Uric Acid Ribonucleoside
Journal of Biological Chemistry, 1963 Leonard Laster, Alberta Blair
openalex +4 more sources
Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractProtecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection and oligonucleotide synthesis.
Geeta Meher +2 more
openaire +6 more sources
Redox Biology, 2016 Complex metabolism is thought to occur exclusively in the crowded intracellular environment. Here we report that diluted enzymes from lysed human leukocytes produce extracellular energy.
John B. Hibbs Jr. +2 more
doaj +1 more source
Nature Communications, 2020 Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and ...
Sathya Balachander +14 more
doaj +1 more source
Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]
, 2019 Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F. +4 more
core +1 more source
Molecules, 2019 Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been reported, the development of highly efficient enzymes for industrial applications is still in high ...
Gaofei Liu +4 more
doaj +1 more source
Permeability of Coxiella burnetii to ribonucleosides [PDF]
Microbiology, 2002 Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D. Miller, Herbert A. Thompson
openaire +3 more sources