Results 41 to 50 of about 26,264 (280)

Systematic transcriptome wide analysis of lncRNA-miRNA interactions [PDF]

, 2012
Long noncoding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs which have now increasingly been shown to be involved in a wide variety of biological processes as regulatory molecules. Little is known regarding the regulatory interactions between noncoding RNA classes.
arxiv   +1 more source

A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic

Orphanet Journal of Rare Diseases, 2021
Background Hydroxyurea is one of the earliest drugs that showed promise in the management of haemoglobinopathies that include β-thalassaemia and sickle cell disease.
Nirmani Yasara, Anuja Premawardhena, Sachith Mettananda   +2 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

Molecules, 2020
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation.
Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot   +9 more
doaj   +1 more source

Fluorescent RNA cytosine analogue - an internal probe for detailed structure and dynamics investigations [PDF]

, 2017
The bright fluorescent cytosine analogue tCO stands out among fluorescent bases due to its virtually unquenched fluorescence emission in duplex DNA. However, like most reported base analogues, it has not been thoroughly characterized in RNA.
A Fire, A Wittrup, AA Kuznetsova, AA Tanpure, AA Tanpure, B Dumat, CC Smith, CE Aitken, D Haussecker, D Shin, D Stone, EA Dethoff, G Mata, G Stengel, G Stengel, HM Al-Hashimi, I König, JD Stephenson, JJ Sakon, K Börjesson, K-Y Lin, KC Engman, LM Wilhelmsson, LS McCoy, M Haeussler, M Jinek, M Sholokh, M Sustarsic, MG Pawar, MP Foster, NA Kuznetsov, O Shalem, P Bielecka, P Sandin, P Sandin, P Tompa, R Crawford, RL Juliano, RW Sinkeldam, S Preus, S Preus, S Preus, S Sindbert, SJ Strickler, SM Reilly, SR Holbrook, T Fessl, V Posse, W Liu, X Li, Y Velmurugu, YH Shi   +51 more
core   +2 more sources

DNA Polymerases Engineered by Directed Evolution to Incorporate Nonstandard Nucleotides

Frontiers in Microbiology, 2014
DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ribonucleoside triphosphates. However, polymerases that can accept
Roberto eLaos, John Michael Thomson, Steven Albert Benner   +2 more
doaj   +1 more source

Synthesis and enzymatic evaluation of the guanosine analogue 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG): insights into the phosphorolysis reaction mechanism based on the blueprint transition state: SN1 or SN2? [PDF]

, 2010
A modified experimental procedure for the synthesis of MESG (2-amino-6-mercapto-7-methylpurine ribonucleoside) 1 has been successfully performed and its full characterization is presented.
Basso, Luiz A., Dias, Silvio L.P., Dupont, Jairton, Lapis, Alexandre A.M., Neto, Brenno A.D., Netz, Paulo A., Santos, Diógenes S., Spencer, John, Tamborim, Silvia M.   +8 more
core   +2 more sources

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation

Beilstein Journal of Organic Chemistry, 2016
A series of seventeen β-hydroxyphosphonate ribonucleoside analogues containing 4-substituted-1,2,3-triazoles was synthesized and fully characterized. Such compounds were designed as potential inhibitors of the cytosolic 5’-nucleotidase II (cN-II), an ...
Tai Nguyen Van, Audrey Hospital, Corinne Lionne, Lars P. Jordheim, Charles Dumontet, Christian Périgaud, Laurent Chaloin, Suzanne Peyrottes   +7 more
doaj   +1 more source

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress [PDF]

, 2010
Decades of study have revealed more than 100 ribonucleoside structures incorporated as post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional dynamics of this conserved system are unclear. To this end, we developed a highly
Clement T. Y. Chan, Koli Taghizadeh, Madhu Dyavaiah, Michael S. DeMott, Nancy Maizels, Peter C. Dedon, Thomas J. Begley   +6 more
core   +4 more sources

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources