Results 61 to 70 of about 22,086 (209)

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta‐Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
A detergent‐based method, combined with immunoprecipitation using an anti‐P‐body component‐specific antibody, was used to isolate RNAs associated with RNA processing bodies (PBs) from both neuronal and glial cells. In neurons, β‐amyloid oligomers helped to trap specific mRNAs related to neuronal differentiation into PBs.
Sritama Ray, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

From MS1 to Structure: A Van Krevelen–DBE–Aromaticity‐Based Framework for Annotating Specialized Metabolites via High‐Resolution Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 39, Issue 24, 30 December 2025.
ABSTRACT Rationale Classifying specialized metabolites in untargeted metabolomics remains a major challenge, particularly when relying solely on high‐resolution mass spectrometry (HRMS) data at the MS1 level. Traditional approaches using Van Krevelen diagrams often lack sufficient resolution to distinguish structurally similar metabolite classes ...
Nerilson M. Lima, Luana A. Pereira, Lucas S. Tironi, Matheus P. G. do Carmo, Milbya L. Costa, Renato A. Oliveira, Salva Asghar, Vinicius Fortes da Silva   +7 more
wiley   +1 more source

A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides

Chemical and Pharmaceutical Bulletin, 1970
Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid,
TOHRU UEDA, IKUKO KAWAI
openaire   +2 more sources

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Degradation of nucleic acids with ozone. I. Degradation of nucleobases,ribonucleosides and ribonucleoside-5'-monophosphates.

Chemical and Pharmaceutical Bulletin, 1981
The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases.
K, Ishizaki, N, Shinriki, A, Ikehata, T, Ueda   +3 more
openaire   +2 more sources

Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice

Pharmacology Research & Perspectives, 2019
Cytarabine (Ara‐C) is a nucleoside analog used in the treatment of acute myeloid leukemia (AML). Despite the many years of clinical use, the identity of the transporter(s) involved in the disposition of Ara‐C remains poorly studied.
Jason T. Anderson, Shuiying Hu, Qiang Fu, Sharyn D. Baker, Alex Sparreboom   +4 more
doaj   +1 more source

The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from neonatal piglets

Journal of Animal Science and Biotechnology, 2012
In the present study, the effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on long-chain fatty acid oxidation by hepatocytes isolated from suckled neonatal pig liver (a low ketogenic and lipogenic tissue) was tested.
Xi Lin, Matsey Gary, Odle Jack
doaj   +1 more source

Abiotic Ribonucleoside Formation in Aqueous Microdroplets: Mechanistic Exploration, Acidity, and Electric Field Effects

ChemistryEurope
Aqueous microdroplets have been reported to dramatically increase the rate of chemical reactions. Proposed mechanisms for this acceleration include confinement effects upon droplet evaporation, and Brønsted acid or electric field catalysis at the air ...
Maciej Piejko, Javier E. Alfonso‐Ramos, Joseph Moran, Thijs Stuyver   +3 more
doaj   +1 more source

Solution phase synthesis of short oligoribonucleotides on a precipitative tetrapodal support

Beilstein Journal of Organic Chemistry, 2014
An effective method for the synthesis of short oligoribonucleotides in solution has been elaborated. Novel 2'-O-(2-cyanoethyl)-5'-O-(1-methoxy-1-methylethyl) protected ribonucleoside 3'-phosphoramidites have been prepared and their usefulness as building
Alejandro Gimenez Molina, Amit M. Jabgunde, Pasi Virta, Harri Lönnberg   +3 more
doaj   +1 more source