Results 71 to 80 of about 26,264 (280)

A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides

Chemical and Pharmaceutical Bulletin, 1970
Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid,
Ikuko Kawai, Tohru Ueda
openaire   +3 more sources

Characterization of novel beta-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae.

, 2009
The pneumococcus obtains its energy from the metabolism of host glycosides. Therefore, efficient degradation of host glycoproteins is integral to pneumococcal virulence.
Andrew, Peter W, Homer, Karen A, Rao, Susmitha G, Terra, Vanessa S, Yesilkaya, Hasan   +4 more
core   +2 more sources

A multidimensional platform for the purification of non-coding RNA species [PDF]

, 2013
A renewed interest in non-coding RNA (ncRNA) has led to the discovery of novel RNA species and post-transcriptional ribonucleoside modifications, and an emerging appreciation for the role of ncRNA in RNA epigenetics.
Anderson, Azarani, Barciszewska, Batey, Beier, Bernstein, Brown, Burns, Chan, Chan, Chan, Chee Sheng Ng, Chen Gu, Chia-Hua Ho, Chomczynski, Chomczynski, Chow, Cunningham, Dame, Dame, Dan Su, Dickman, Dominissini, Dong, Dumnoensun Pruksakorn, Duro, Easton, Erin G. Prestwich, Fabian Hia, Fremont, Galasso, Gilar, Gjerde, Hammann, Holden, Hongping Dong, Horie, I. Ramesh Babu, Jahn, Janse, Janse, Jia, Jones, Kato, Kim, Krowczynska, Levin, Li, Likic, Lujambio, Lukavsky, Matera, Megan E. McBee, Miyauchi, Mullineux, Nagele, Nilsen, Noll, Ozsolak, Ozsolak, Parvez, Pei-Yong Shi, Perez-Novo, Peter C. Dedon, Peter Rainer Preiser, Phizicky, Rinn, Rio, Seong, Sharp, Shi, Sylvie Alonso, Uchiyama, Waghmare, Wu, Wu, Wyatt, Xue, Yan Ling Joy Pang, Yok Hian Chionh, Zou   +80 more
core   +4 more sources

Characterization of ADA‐GEL Based Hydrogels Combined with Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Human Platelet Lysate (HPL) for 3D (Bio)Printing

Macromolecular Materials and Engineering, EarlyView.
Alginate dialdehyde (ADA)‐gelatin (GEL) hydrogels are supplemented with mesoporous bioactive glass nanoparticles (MBGNs) and human platelet lysate (HPL) to enhance the biological performance of 3D printed scaffolds. Improved printability and higher shape fidelity are observed by incorporating 0.1% (w/v) MBGNs.
Yijun Zhao, Faina Bider, Aldo R. Boccaccini   +2 more
wiley   +1 more source

Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage [PDF]

, 2015
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational
Begley, Thomas J., Begley, Ulrike, Clark, Ryan, Dedon, Peter C., Dziergowska, Agnieszka, Endres, Lauren, Gu, Chen, Małkiewicz, Andrzej, Melendez, J. Andres   +8 more
core   +3 more sources

Optical Probes for Cellular Imaging of G‐quadruplexes: Beyond Fluorescence Intensity Probes

Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.
DNA and RNA can fold into tetra‐stranded helical structures known as G‐quadruplexes (G4s). There is mounting evidence suggesting that these structures have important biological roles. In this minireview we discuss advances in the design of optical probes for the detection of G4s that offer intensity‐independent readouts that address limitations of ...
Jenna Robinson, Aatikah Majid, Marina K. Kuimova, Ramon Vilar   +3 more
wiley   +2 more sources

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation [PDF]

, 2013
AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while ...
Ahmadian, An, Anthony, Arita, Arkan, Bain, Barnes, Barré, Bauwens, Berggreen, Bourron, Boyle, Boyle, Brooks, Buhl, Carey, Carling, Carling, Caton, Chakrabarti, Chaves, Chavez, Chen, Chen, Cheung, Cinti, Cool, Coppari, Daval, Daval, Ducharme, Duncan, Dzamko, Egan, Emerling, Eringa, Fazakerley, Fischer, Fisher, Flechtner-Mors, Foretz, Fox, Fryer, Gaidhu, Gaidhu, Gaidhu, Gaidhu, Galic, Garton, Gauthier, Gauthier, Geraghty, Giri, Glass, Grimaldi, Guigas, Gurriarán-Rodríguez, Gustafson, Habinowski, Hardie, Hawley, Hawley, Hawley, Henin, Hevener, Holmes, Hutchinson, Huypens, Ian P. Salt, Iglesias, Imamura, Iwatsubo, Jeon, Jeong, Jiao, Kanda, Kelly, Kim, Kitade, Koh, Kohlstedt, Koistinen, Kola, Kou, Kramer, Kristensen, Lee, Lee, Li, Lihn, Lihn, Lin, Lin, Liu, Lorente-Cebrián, Luo, López, Lönnqvist, MacDougald, Martínez-Agustin, Marzolla, McBride, McGee, McInnes, McInnes, Minokoshi, Mulligan, Narkar, Nguyen, Nishimura, Nishimura, Odegaard, Ojuka, Ojuka, Orci, Pagnon, Park, Peng, Perrotti, Peyton, Polakof, Pulinilkunnil, Rasmussen, Reihill, Reshef, Reshef, Rosen, Saberi, Sag, Sakamoto, Sakamoto, Sakaue, Sakoda, Salt, Salt, Salt, Samovski, Sano, Sarah J. Mancini, Schwenk, Scott, Shi, Silvia Bijland, Solinas, Sponarova, Steinberg, Steinberg, Su, Sullivan, Sun, Takekoshi, Tam, Tang, Turer, Vandanmagsar, Vats, Vaughan, Vila-Bedmar, Villena, Vingtdeux, Viollet, Vucetic, Wan, Wang, Wang, Wang, Watt, Winder, Woods, Wu, Xiao, Xu, Yamauchi, Yang, Yin, Yuen, Zhang, Zhang, Zhang, Zhang, Zhou, Zimmermann, Zmijewski   +182 more
core   +1 more source

Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2

Trials, 2021
A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the ...
Wendy Holman, Wayne Holman, Stacy McIntosh, Wendy Painter, George Painter, Jim Bush, Oren Cohen   +6 more
doaj   +1 more source

Optimised Ribosome Profiling Reveals New Insights Into Translational Regulation in Synchronised Chlamydomonas reinhardtii Cultures

Plant, Cell &Environment, EarlyView.
ABSTRACT Deep sequencing of ribosome footprints, also known as ribosome profiling (Ribo‐seq), enables the quantification of mRNA translation and a comprehensive view of the translatome landscape. Here, we report an optimised Ribo‐seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).
Yen‐Ling Lin, Eva Yuhua Kuo, Shih‐Yi Wang, Chih‐Chi Lee, Su‐Chiung Fang   +4 more
wiley   +1 more source

Incorporation of Histamine Ribonucleoside into Soluble Proteins [PDF]

Nature, 1966
ISOTOPICALLY labelled histamine ribonucleoside can be detected in the urine of experimental animals after intraperitoneal administration of either 2(ring)−14C-labelled histamine1, or similarly labelled histamine-adenine-dinucleotides2. However, in such experiments the quantities of histamine ribonucleoside recovered from the urine represent only a ...
Frieda Ungar, Spyridon G.A. Alivisatos, George A. Mourkides   +2 more
openaire   +3 more sources