Results 81 to 90 of about 26,264 (280)
Probabilistic modeling of occurring substitutions in PAR-CLIP data [PDF]
arXiv, 2015 Photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation (PAR-CLIP) is an experimental method based on next-generation sequencing for identifying the RNA interaction sites of a given protein. The method deliberately inserts T-to-C substitutions at the RNA-protein interaction sites, which provides a second layer of evidence ...
arxiv
Gene expression analysis in microdissected renal tissue - Current challenges and strategies [PDF]
, 2002 The architecture and compartmentalization of the kidney has stimulated the development of an array of microtechniques to study the functional differences between the distinct nephron segments. With the vast amounts of genomic sequence data now available,
Cohen, C. D., Kretzler, M.
core +1 more source
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver. [PDF]
PLoS ONE, 2015 Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct ...
Shudong Liu +5 more
doaj +1 more source
ChemBioChem, Volume 26, Issue 11, June 3, 2025.In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout +1 more
wiley +1 more source
Mutarotation of tetramethylglucose catalyzed by ribonucleosides
Tetrahedron Letters, 1997 Abstract The inherent catalytic ability of various 2′, 3′, 5′ tri-OTBS protected RNA nucleosides in facilitating mutarotation of tetramethylglucose in benzene was investigated. Nucleosides A, G, and Ψ showed modest rate enhancements (3–5 fold) over the uncatalyzed rate whereas C demonstrated a rate increase of over 20-fold.
Christian Melander, David A. Horne
openaire +2 more sources
Synthesis of [5‘-13C]Ribonucleosides and 2‘-Deoxy[5‘-13C]ribonucleosides [PDF]
The Journal of Organic Chemistry, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Takeshi Sekine +2 more
openaire +3 more sources
A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core +1 more source
Monitoring genetic population biomarkers for wastewater-based epidemiology [PDF]
, 2017 We report a rapid “sample-to-answer” platform that can be used for the quantitative monitoring of genetic biomarkers within communities through the analysis of wastewater. The assay is based on the loop-mediated isothermal amplification (LAMP) of nucleic
Cooper, Jonathan M. +4 more
core +3 more sources
Construction of a nrdA::luxCDABE Fusion and Its Use in Escherichia coli as a DNA Damage Biosensor
Sensors, 2008 The promoter of nrdA gene which is related with DNA synthesis was used to construct a DNA damage sensitive biosensor. A recombinant bioluminescent E.
Man Bock Gu +3 more
doaj
British Journal of Haematology, Volume 206, Issue 6, Page 1585-1592, June 2025.Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs +13 more
wiley +1 more source