Results 231 to 240 of about 846,528 (387)

Model‐Guided Systematic Metabolic Engineering for Enhanced Spinosad Biosynthesis in Saccharopolyspora spinosa NHF132

open access: yesAdvanced Science, EarlyView.
A genome‐scale model guided the systematic metabolic engineering of Saccharopolyspora spinosa, enabling a 5.5‐fold boost in the green bioinsecticide spinosad to 1.8 g L−1 and establishing an actinomycete framework for complex natural products overproduction.
Shuliu Wang   +9 more
wiley   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng   +5 more
wiley   +1 more source

On-tissue derivatization for mass spectrometry imaging reveals the distribution of short chain fatty acids in murine digestive tract. [PDF]

open access: yesFront Cell Infect Microbiol
Nakagawa K   +6 more
europepmc   +1 more source

Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis [PDF]

open access: bronze, 2013
Jun Yuan   +8 more
openalex   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

open access: yesAdvanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin   +8 more
wiley   +1 more source

The multifaceted roles of ribosomal P complex in cancer. [PDF]

open access: yesWorld J Surg Oncol
Yan B   +6 more
europepmc   +1 more source

Biological effect of ribosomal protein L32 on human breast cancer cell behavior

open access: hybrid, 2020
Lu Xu   +6 more
openalex   +2 more sources

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