Results 241 to 250 of about 699,944 (333)

Ribosomal protein mutation suppresses gonadal leader cell migration defects in mig-17/ADAMTS mutants in Caenorhabditis elegans. [PDF]

Sci Rep
Kim HS, Mitsuzumi K, Kondo S, Yamaoka R, Ihara S, Otsuka H, Yoshikata C, Kubota Y, Tomohiro T, Fujiwara T, Kimura K, Motegi F, Shibata Y, Takahashi M, Nishiwaki K.   +14 more
europepmc   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Peptidic Tryptophan Halogenation by a Promiscuous Flavin‐Dependent Enzyme

Angewandte Chemie, EarlyView.
ChlH, a flavin‐dependent tryptophan halogenase, was reconstituted in vitro and capable of modifying a wide array of diverse peptidic substrates. This suggests a potential use in the biocatalytic production of chlorinated peptides. Abstract Amino acids undergo numerous enzymatic modifications.
Andrew J. Rice, Mayuresh G. Gadgil, Paola Bisignano, Richard A. Stein, Hassane S. Mchaourab, Douglas A. Mitchell   +5 more
wiley   +2 more sources

Harnessing Physiological Shear Stress in a Perfusion Bioreactor for Enhanced Endothelialization of Small‐Diameter Vascular Grafts

Advanced NanoBiomed Research, EarlyView.
Traditional static culture provides limited physiological relevance for evaluation of vascular grafts. A perfusion bioreactor system can provide more accurate in vitro model for evaluation of vascular grafts, exposing endothelial cells on 3D structure to physiological or pathological shear stress.
Praveesuda L. Michael, Yuen Ting Lam, Timothy C. Mitchell, Miguel Santos, Alex H. P. Chan, Xinying Liu, Angus J. Grant, Matthew J. Moore, David F. Fletcher, Richard P. Tan, Steven G. Wise   +10 more
wiley   +1 more source

Real‐Time Eco–AI, Electrophoresis‐Correlative Data‐Dependent Acquisition with AI‐Based Data Processing Broadens Access to Single‐Cell Mass Spectrometry Proteomics

Angewandte Chemie, EarlyView.
An affordable single‐cell proteomics workflow combines capillary electrophoresis, real‐time ion sorting, and AI‐aided spectral deconvolution to profile early Xenopus embryonic cells. Despite using a legacy Orbitrap, this strategy matches or exceeds the sensitivity of modern instruments, uncovering proteome dynamics at sub‐nanogram scale.
Bowen Shen, Fei Zhou, Peter Nemes
wiley   +2 more sources

Causal Relationship Between Mitochondrial Characteristics and Inflammatory Bowel Disease and Its Subtypes: Evidence for Mendelian Randomization. [PDF]

JGH Open
Cai Y, Fan H, Zhao J, Fu G.
europepmc   +1 more source

Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper‐Dependent Metalloenzymes

Angewandte Chemie, EarlyView.
DUF3328 is an enigmatic enzyme family implicated in diverse transformations in fungal natural product biosynthesis, yet its functions remain largely underexplored. Through biochemical characterization of the cyclochlorotine hydroxylase CctR, we define DUF3328 as a family of copper‐dependent metalloenzymes.
Wentao Huang, Jakob K. Reinhardt, Anru Tian, Xiao Zhang, Binghui Li, Noah Gould, Sashirekha Nallapati, Alexander R. Ivanov, Yi Wang, Jason J. Guo, David E. Budil, Jing‐Ke Weng   +11 more
wiley   +2 more sources

Translational reprogramming under heat stress: a plant's perspective. [PDF]

R Soc Open Sci
Smith M, Taqrir Akramin A, Balcerowicz M.   +2 more
europepmc   +1 more source

Crown Ether–Peptide Rotaxanes

Angewandte Chemie, EarlyView.
The synthesis of crown ether‐peptide rotaxanes is reported, incorporating a broad range of canonical and unnatural peptides into a threaded peptide backbone without the need for additional nonamide template sites in the axle. The 24C8 macrocycle is locked on the glycine residue used to assemble the rotaxane, allowing the formation of different ...
Peng‐Lai Wang, Peng Chen, Raorao Yang, Daniel J. Tetlow, Zhi‐Hui Zhang, Jing Han, Stephen D. P. Fielden, Prodip Howlader, Liang Zhang, David A. Leigh   +9 more
wiley   +2 more sources

Regulation of Hindbrain Vascular Development by <i>rps20</i> in Zebrafish. [PDF]

Cells
Shen X, Wen Z, Deng S, Qiu Y, Ma W, Dong X, Gong J, Zhang Y, Liu D, Xu B.   +9 more
europepmc   +1 more source