Results 251 to 260 of about 846,528 (387)

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Integrated Machine Learning and Structure-Based Virtual Screening Identifies Natural Product Targeting 50S Ribosome Inhibitory Activity Against <i>Cutibacterium acnes</i>. [PDF]

Molecules
Liu J, Tong HHY, Zheng H, Lei MIF, Li S.
europepmc   +1 more source

A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit

, 2009
Lisa M. Sharpe Elles, Michael T. Sykes, James R. Williamson, Olke C. Uhlenbeck   +3 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Draft genome sequence of a potential probiotic <i>Pediococcus acidilactici</i> RTMP1 isolated from fecal samples of Speckled goats in South Africa. [PDF]

Microbiol Resour Announc
Modiba MR, Makete G, Alayande KA, Ngxumeshe AM, Sihlangu E, Mamphogoro TP.   +5 more
europepmc   +1 more source

Nucleotide sequence of a cDNA encoding anotherTrypanosoma cruziacidic ribosomal P2 type protein (TcP2b) [PDF]

, 1992
Martı́n Vázquez, Alejandro G. Schijman, Alfredo Panebra, Mariano J. Levin   +3 more
openalex   +1 more source

DNA Origami and Its Applications in Synthetic Biology

Advanced Science, EarlyView.
This review provides a comprehensive summary of recent advancements in DNA origami for synthetic biology, emphasizing two key areas: the precise construction and dynamic regulation of extracellular‐to‐intracellular, and the synergistic integration with cell‐free systems.
Yaning Fang, Xuexin Chen, Qingsheng Qi, Min Lin, Quanfeng Liang   +4 more
wiley   +1 more source

Collision-induced ribosome degradation driven by ribosome competition and translational perturbations. [PDF]

Nat Commun
Li S, Shounai O, Kato M, Ikeuchi K, Inada T.   +4 more
europepmc   +1 more source

Testing the classical two‐tRNA‐site model for the ribosomal elongation cycle [PDF]

, 1984
Alexander S. Spirin
openalex   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source