Results 41 to 50 of about 846,528 (387)

cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins [PDF]

, 2008
mRNA localization is a conserved post-transcriptional process crucial for a variety of systems. Although several mechanisms have been identified, emerging evidence suggests that most transcripts reach the protein functional site by moving along ...
AMORESANO, ANGELA, C. Cirulli, PIETROPAOLO, CONCETTA, PUCCI, PIETRO, RUSSO, ANNAPINA, RUSSO, GIULIA   +5 more
core   +1 more source

SINA: Accurate high-throughput multiple sequence alignment of ribosomal RNA genes

Bioinform., 2012
MOTIVATION In the analysis of homologous sequences, computation of multiple sequence alignments (MSAs) has become a bottleneck. This is especially troublesome for marker genes like the ribosomal RNA (rRNA) where already millions of sequences are publicly
E. Pruesse, J. Peplies, F. Glöckner
semanticscholar   +1 more source

Our current understanding of the toxicity of altered mito-ribosomal fidelity during mitochondrial protein synthesis: What can it tell us about human disease?

Frontiers in Physiology, 2023
Altered mito-ribosomal fidelity is an important and insufficiently understood causative agent of mitochondrial dysfunction. Its pathogenic effects are particularly well-known in the case of mitochondrially induced deafness, due to the existence of the ...
Antón Vila-Sanjurjo, Natalia Mallo, John F. Atkins, Joanna L. Elson, Joanna L. Elson, Paul M. Smith   +5 more
doaj   +1 more source

Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group

Frontiers in Genetics, 2018
Introduction: The multi-copied genes coding for the human 18, 5.8, and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA.
Elena M. Malinovskaya, Elizaveta S. Ershova, Vera E. Golimbet, Lev N. Porokhovnik, Nataliya A. Lyapunova, Serguey I. Kutsev, Natalia N. Veiko, Svetlana V. Kostyuk   +7 more
doaj   +1 more source

Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Breast Cancer Research, 2022
Background Ribosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere translational machineries, ribosomes might play an active role in tumor initiation and progression ...
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner, Peter Bronsert   +15 more
doaj   +1 more source

Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

Redox Biology, 2023
Upon exposure to internal or environmental insults, ribosomes stand sentinel. In particular, stress-driven dysregulation of ribosomal homeostasis is a potent trigger of adverse outcomes in mammalians.
Junjie Sun, Juil Kim, Hoyoung Jeong, Dasom Kwon, Yuseok Moon   +4 more
doaj   +1 more source

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

Science, 2020
Metastasis: A matter of translation? Solid tumors shed a small number of cancer cells into the bloodstream, some of which are believed to contribute to metastasis.
R. Ebright, Sooncheol Lee, Ben S. Wittner, Kira L. Niederhoffer, Benjamin T. Nicholson, A. Bardia, S. Truesdell, Devon F. Wiley, Benjamin Wesley, S. Li, Andy Mai, N. Aceto, Nicole Vincent-Jordan, A. Szabolcs, Brian Chirn, J. Kreuzer, Valentine Comaills, M. Kalinich, W. Haas, D. Ting, M. Toner, S. Vasudevan, D. Haber, S. Maheswaran, D. Micalizzi   +24 more
semanticscholar   +1 more source

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

Science, 2020
Shifting frames to make more proteins Severe acute respiratory syndrome coronavirus 2 critically depends on the ribosomal frameshifting that occurs between two large open reading frames in its genomic RNA for expression of viral replicase.
P. R. Bhatt, A. Scaiola, G. Loughran, M. Leibundgut, A. Kratzel, Romane Meurs, R. Dreos, Kate M. O’Connor, Angus E. McMillan, J. Bode, V. Thiel, D. Gatfield, J. F. Atkins, N. Ban   +13 more
semanticscholar   +1 more source

Combined DNA Methylation and Gastric Microbiome Marker Predicts Helicobacter pylori-Negative Gastric Cancer

Gut and Liver
Background/Aims: While DNA methylation and gastric microbiome are each associated with gastric cancer (GC), their combined role in predicting GC remains unclear.
Min-Jeong Kim, Han-Na Kim, Jonathan P. Jacobs, Hyo-Joon Yang   +3 more
doaj   +1 more source

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

Haematologica, 2014
Diamond-Blackfan anemia is a congenital erythroid hypoplasia caused by functional haploinsufficiency of genes encoding ribosomal proteins. Mutations involving the ribosomal protein S19 gene are detected in 25% of patients.
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Ute Modlich, Michael Rothe, Axel Schambach, Johan Flygare, Stefan Karlsson   +7 more
doaj   +1 more source