Results 41 to 50 of about 699,944 (333)

Roles of transcriptional and translational control mechanisms in regulation of ribosomal protein synthesis in Escherichia coli [PDF]

, 2017
Bacterial ribosome biogenesis is tightly regulated to match nutritional conditions and to prevent formation of defective ribosomal particles. InEscherichia coli, most ribosomal protein (r-protein) synthesis is coordinated with rRNA synthesis by a ...
Burgos, Hector L, Gourse, Richard L, O\u27Connor, Kevin, Sanchez-Vazquez, Patricia   +3 more
core   +3 more sources

Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer

Breast Cancer Research, 2022
Background Ribosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere translational machineries, ribosomes might play an active role in tumor initiation and progression ...
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner, Peter Bronsert   +15 more
doaj   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources

Combined DNA Methylation and Gastric Microbiome Marker Predicts Helicobacter pylori-Negative Gastric Cancer

Gut and Liver
Background/Aims: While DNA methylation and gastric microbiome are each associated with gastric cancer (GC), their combined role in predicting GC remains unclear.
Min-Jeong Kim, Han-Na Kim, Jonathan P. Jacobs, Hyo-Joon Yang   +3 more
doaj   +1 more source

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

Haematologica, 2014
Diamond-Blackfan anemia is a congenital erythroid hypoplasia caused by functional haploinsufficiency of genes encoding ribosomal proteins. Mutations involving the ribosomal protein S19 gene are detected in 25% of patients.
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Ute Modlich, Michael Rothe, Axel Schambach, Johan Flygare, Stefan Karlsson   +7 more
doaj   +1 more source

Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function [PDF]

, 2020
Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene to the connectivity $k$ of the corresponding protein in the PPI networks ...
Cimini, Giulio, Dilucca, Maddalena, Giansanti, Andrea   +2 more
core   +2 more sources

Ribosomal Proteins in Ribosome Assembly

Biomolecules
Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
openaire   +3 more sources

Nascent Ribosomes [PDF]

Cell, 2001
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
openaire   +2 more sources

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

Tumor Biology, 2017
Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation ...
Meng Pu, Jianlin Wang, Qike Huang, Ge Zhao, Congcong Xia, Runze Shang, Zhuochao Zhang, Zhenyuan Bian, Xishegn Yang, Kaishan Tao   +9 more
doaj   +1 more source

The ribosome returned [PDF]

Journal of Biology, 2009
Since the mid-1990s, insights obtained from electron microscopy and X-ray crystallography have transformed our understanding of how the most important ribozyme in the cell, the ribosome, catalyzes protein synthesis. This review provides a brief account of how this structural revolution came to pass, and the impact it has had on our understanding of how
openaire   +3 more sources