Results 251 to 260 of about 534,315 (335)

Ribosomal DNA copy number is associated with body mass in humans and other mammals. [PDF]

Nat Commun
Law PP, Mikheeva LA, Rodriguez-Algarra F, Asenius F, Gregori M, Seaborne RAE, Yildizoglu S, Miller JRC, Tummala H, Mesnage R, Antoniou MN, Li W, Tan Q, Hillman SL, Rakyan VK, Williams DJ, Holland ML.   +16 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Ribosomal DNA copy number is associated with body mass in humans and other mammals

, 2023
Law PP, Rodriguez-Algarra F, Asenius F, Gregori M, Seaborne RA, Yildizoglu S, Miller JR, Mesnage R, Antoniou MN, Li W, Tan Q, Hillman SL, Rakyan VK, Williams DJ, Holland ML.   +14 more
europepmc   +1 more source

Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress

, 2007
Sridevi Yadavilli, Vijay Hegde, Walter Deutsch   +2 more
openalex   +1 more source

Seasonal shifts in population structure of Vibrio vulnificus in an estuarine environment as revealed by partial 16S ribosomal DNA sequencing [PDF]

, 2003
Meilan Lin, John R. Schwarz
openalex   +1 more source

Participation of Deoxyribonucleic Acid Polymerase a in Amplification of Ribosomal Deoxyribonucleic Acid in Xenopus laevis [PDF]

, 1981
Zimmermann, Wolfgang
core  

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Fluorescence in situ Hybridization Analysis of Oligonucleotide 5S Ribosomal DNA, 45S Ribosomal DNA, and (TTTAGGG)3 Locations in Gloriosa superba L.

Cytogenet Genome Res
Zhao H, Wang D, Li H, Li S, Wang Y, Xu A, Yang C, Li G, Wang Y, Zhang L.   +9 more
europepmc   +1 more source

Elucidation of intragenomic variation of ribosomal DNA sequences in the enigmatic fungal genus Ceraceosorus, including a newly described species Ceraceosorus americanus. [PDF]

IMA Fungus
Kijpornyongpan T, Noble MC, Piątek M, Lutz M, Aime MC.   +4 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source