Results 131 to 140 of about 59,620 (205)

Adaptation of translational machinery in malaria parasites to accommodate translation of poly-adenosine stretches throughout its life cycle [PDF]

, 2019
Malaria is caused by unicellular apicomplexan parasites of the ...
Djuranovic, Sergej, Djuranovic, Slavica Pavlovic, Erath, Jessey   +2 more
core   +1 more source

Structural and Functional Insights into Viral Programmed Ribosomal Frameshifting. [PDF]

Annu Rev Virol, 2023
Hill CH, Brierley I.
europepmc   +1 more source

Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif

mBio
Encephalomyocarditis virus (EMCV) has been an important model RNA virus for decades. Although most of the EMCV proteins are obtained via proteolytic cleavage of a long polyprotein, 2B* is expressed from a short overlapping open reading frame via an ...
Samantha K. Nguyen, Nadine Anders, Stephen Holmes, Henry G. Barrow, Nina Lukhovitskaya, Aminu S. Jahun, Iliana Georgana, Laura G. Caller, James R. Edgar, Stephen C. Graham, Edward Emmott, Andrew E. Firth, Hazel Stewart   +12 more
doaj   +1 more source

High-Throughput Screening for a SARS-CoV-2 Frameshifting Inhibitor Using a Cell-Free Protein Synthesis System

BioTechniques
Programmed-1 ribosomal frameshifting (-1 PRF) is a translational mechanism adopted by some viruses, including SARS-CoV-2. To find a compound that can inhibit -1 PRF in SARS-CoV-2, we set up a high-throughput screening system using a HeLa cell extract ...
Kodai Machida, Rin Tanaka, Seraya Miki, Shotaro Noseda, Mayumi Yuasa-Sunagawa, Hiroaki Imataka   +5 more
doaj   +1 more source

Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

Nature Communications
Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3 GCU has been shown to induce −1 ribosomal frameshifting on GCA alanine codons, and proposed to read a two-base codon instead of a canonical ...
Shruthi Krishnaswamy, Shirin Akbar, Daniel S. D. Larsson, Yang Chen, Maria Selmer   +4 more
doaj   +1 more source

Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding. [PDF]

Mol Cell, 2022
Loughran G, Fedorova AD, Khan YA, Atkins JF, Baranov PV.   +4 more
europepmc   +1 more source

Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting. [PDF]

Antiviral Res, 2022
Varricchio C, Mathez G, Pillonel T, Bertelli C, Kaiser L, Tapparel C, Brancale A, Cagno V.   +7 more
europepmc   +2 more sources

Functionality and translation fidelity characterization of mRNA vaccines using platform based mass spectrometry detection

npj Vaccines
The success of mRNA-based therapeutics and vaccines is attributed to their rapid development, adaptability, and scalable production. Modified ribonucleotides like N1-methylpseudouridine enhance stability and reduce immunogenicity but were recently found ...
Alyssa Q. Stiving, Benjamin W. Roose, Christopher Tubbs, Mark Haverick, Ashley Gruber, Richard R. Rustandi, Jesse Kuiper, Matthew Schombs, Hillary Schuessler, Xuanwen Li   +9 more
doaj   +1 more source

Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2022
Halwas K, Döring LM, Oehlert FV, Dohmen RJ.   +3 more
europepmc   +1 more source

Comprehensive analysis of yeast +1 ribosomal frameshifting unveils a novel stimulator supporting two distinct frameshifting mechanisms. [PDF]

Nucleic Acids Res
Fenton DA, Bożko M, Świrski MI, Loughran G, Yordanova MM, Kufel J, Atkins JF, Baranov PV.   +7 more
europepmc   +2 more sources