Results 121 to 130 of about 59,620 (205)

REPARATION : ribosome profiling assisted (re-)annotation of bacterial genomes [PDF]

, 2017
Prokaryotic genome annotation is highly dependent on automated methods, as manual curation cannot keep up with the exponential growth of sequenced genomes.
Giess, Adam, Jonckheere, Veronique, Menschaert, Gerben, Ndah, Elvis, Valen, Eivind, Van Damme, Petra   +5 more
core   +1 more source

Transfer RNA Modification Status Influences Retroviral Ribosomal Frameshifting

Virology, 1999
The possibility of whether tRNAs with and without a highly modified base in their anticodon loop may influence the level of retroviral ribosomal frameshifting was examined. Rabbit reticulocyte lysates were programmed with mRNA encoding UUU or AAC at the frameshift site and the corresponding Phe tRNA with or without the highly modified wyebutoxine (Y ...
Carlson, Bradley A., Kwon, So Yeon, Chamorro, Mario, Oroszlan, Stephen, Hatfield, Dolph L., Lee, Byeong Jae   +5 more
openaire   +2 more sources

Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for experimental validation of the mosaic translation hypothesis

Computational and Structural Biotechnology Journal
The high complexity of eukaryotic organisms enabled their evolutionary success, driven by the diversification of their proteomes. Various mechanisms contributed to this process.
Umut Çakır, Noujoud Gabed, Yunus Emre Köroğlu, Selen Kaya, Senjuti Sinharoy, Vagner A. Benedito, Marie Brunet, Xavier Roucou, Igor S. Kryvoruchko   +8 more
doaj   +1 more source

Investigation of COVID-19 virus mutagenicity and the effect of the NSP13, NSP14, and NSP16 on the -1 ribosomal frameshifting

Frontiers in Virology
The COVID-19 virus is a single-stranded virus from the Coronaviridae family and has a genome of about 29881 bp, which causes acute respiratory disease. One way of transmission of the COVID-19 virus is respiratory, which is the reason for the significant ...
Ali Khanifar, Ali Khanifar, Azin Najafi, Azin Najafi, Jaber Hemmati, Jaber Hemmati, Fatemeh Nouri, Seyed Ali Hosseini, Seyed Ali Hosseini, Mohammad Taheri   +9 more
doaj   +1 more source

Ribosomal Frameshift Signals in Viral Genomes [PDF]

, 2012
Viral genomes contain fewer genes and are more compact than eukaryotic or prokaryotic genomes. Overlapping reading frames are often present in viral genomes and this enables multiple proteins to be made from a single transcript. This genomic layout can serve different purposes: more efficient use of the genome; fewer resources needed for making ...
openaire   +2 more sources

Identification of Two Novel Amalgaviruses in the Common Eelgrass (Zostera marina) and in Silico Analysis of the Amalgavirus +1 Programmed Ribosomal Frameshifting Sites

The Plant Pathology Journal, 2018
The genome sequences of two novel monopartite RNA viruses were identified in a common eelgrass (Zostera marina) transcriptome dataset. Sequence comparison and phylogenetic analyses revealed that these two novel viruses belong to the genus Amalgavirus in ...
doaj   +1 more source

Thermodynamic Control of Ribosomal Frameshifting [PDF]

Biophysical Journal, 2019
Bock, L., Caliskan, N., Korniy, N., Peske, F., Rodnina, M., Grubmüller, H.   +5 more
openaire   +3 more sources

Statistical methodology for ribosomal frameshift detection

Proceedings of the 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics, 2022
Yurovsky, Alisa, Gardin, Justin, Futcher, Bruce, Skiena, Steven   +3 more
openaire   +1 more source

Modular Polymerase Synthesis and Internal Protein Domain Swapping via Dual Opposed Frameshifts in the Ebola Virus L Gene

Pathogens
Sequence analysis of the Zaire ebolavirus (EBOV) polymerase (L gene) mRNA, using online tools, identified a highly ranked −1 programmed ribosomal frameshift (FS) signal including an ideal slippery sequence heptamer (UUUAAAA), with an overlapping coding ...
David B. Stubbs, Jan A. Ruzicka, Ethan W. Taylor   +2 more
doaj   +1 more source

Investigation of possible G-quadruplex formation by GU- and GA-rich repeats and their role in translation

RNA Biology
RNA G-quadruplexes (rG4s) are involved in many aspects of cellular and viral protein expression. rG4s consist of at least two stacks of guanine tetrads that are stabilized by non-Watson-Crick-Franklin base pairs.
Bas M. Morren, Jitske Marcelis, Iza Muradin, René C.L. Olsthoorn   +3 more
doaj   +1 more source