Advanced Science, EarlyView.The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He +6 more
wiley +1 more source
Computer simulations of the bacterial ribosome using a general purpose coarse-grained model MARTINI [PDF]
arXivRibosomes are critical biomolecular nanomachines responsible for protein synthesis in all known organisms. The function and dynamics of ribosomes can be studied using molecular dynamics computer simulations. Although this task remains challenging at atomic level, several studies have reported all-atom molecular dynamics simulations of the entire ...
arxiv
The contamination of rat‐liver polyribosomal preparations by non‐ribosomal proteins [PDF]
, 1969 Garth B. Robinson
openalex +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
Genotype‐phenotype associations in individuals with Diamond Blackfan anaemia
eJHaemIntroduction Diamond Blackfan anaemia (DBA) is a rare disorder characterized by failure of red blood cell production, congenital abnormalities and cancer predisposition, primarily caused by pathogenic germline variants in genes encoding ribosomal ...
D. Matthew Gianferante +6 more
doaj +1 more source
A stochastic model of the production of multiple proteins in cells [PDF]
arXiv, 2014 The production processes of proteins in prokaryotic cells are investigated. Most of the mathematical models in the literature study the production of {\em one} fixed type of proteins. When several classes of proteins are considered, an important additional aspect has to be taken into account, the limited common resources of the cell (polymerases and ...
arxiv
Isolation and Amino Acid Composition of Ribosomal Proteins from Bacillus stearothermophilus [PDF]
, 1969 Steven B. Ansley +2 more
openalex +1 more source
RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
Advanced Science, EarlyView.RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao +15 more
wiley +1 more source
On the Structure of the Initiation and Elongation Rates that Maximize Protein Production in the Ribosome Flow Model [PDF]
arXiv, 2014 Translation is a crucial step in gene expression. During translation, macromolecules called ribosomes "read" the mRNA strand in a sequential manner and produce a corresponding protein. Translation is known to consume most of the cell's energy. Maximizing the protein production rate in mRNA translation, subject to the bounded biomolecullar budget, is ...
arxiv
Amino Acid Differences in a 30 S Ribosomal Protein from Two Strains of Escherichia coli [PDF]
, 1969 Paul S. Sypherd
openalex +1 more source