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Ribosomal Proteins in Ribosome Assembly [PDF]
BiomoleculesRibosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Brigitte Pertschy, Ingrid Zierler
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Differential Stoichiometry among Core Ribosomal Proteins [PDF]
Cell Reports, 2015 Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some ...
Nikolai Slavov +4 more
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Phylogenomics of prokaryotic ribosomal proteins. [PDF]
PLoS ONE, 2012 Archaeal and bacterial ribosomes contain more than 50 proteins, including 34 that are universally conserved in the three domains of cellular life (bacteria, archaea, and eukaryotes).
Natalya Yutin +3 more
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Mitochondrial Ribosomal Proteins and Cancer [PDF]
MedicinaMitochondria play key roles in maintaining cell life and cell function, and their dysfunction can lead to cell damage. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes and are assembled within the mitochondria.
Huiyi Wu +5 more
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The Influence of Extra-Ribosomal Functions of Eukaryotic Ribosomal Proteins on Viral Infection [PDF]
BiomoleculesThe eukaryotic ribosome is a large ribonucleoprotein complex consisting of four types of ribosomal RNA (rRNA) and approximately 80 ribosomal proteins (RPs), forming the 40S and 60S subunits.
Zhongwei Zhao +8 more
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Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
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The other lives of ribosomal proteins [PDF]
Human Genomics, 2010 Despite the fact that ribosomal proteins are the constituents of an organelle that is present in every cell, they show a surprising level of regulation, and several of them have also been shown to have other extra-ribosomal functions, such in replication,
Bhavsar Rital B +2 more
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Archaea/eukaryote-specific ribosomal proteins - guardians of a complex structure [PDF]
Computational and Structural Biotechnology Journal, 2023 In three domains of life, proteins are synthesized by large ribonucleoprotein particles called ribosomes. All ribosomes are composed of ribosomal RNAs (rRNA) and numerous ribosomal proteins (r-protein).
Ivan Kisly, Tiina Tamm
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Ribosome specialization in cancer: a spotlight on ribosomal proteins. [PDF]
NAR CancerAbstractIn the past few decades, our view of ribosomes has changed substantially. Rather than passive machines without significant variability, it is now acknowledged that they are heterogeneous, and have direct regulatory capacity. This ‘ribosome heterogeneity’ comes in many flavors, including in both the RNA and protein components of ribosomes, so ...
Ramalho S, Dopler A, Faller WJ.
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Ribosomal proteins in hepatocellular carcinoma: mysterious but promising [PDF]
Cell & BioscienceRibosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors.
Qian Su +6 more
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