Results 171 to 180 of about 5,783,905 (321)

Molecular Stiffening by Macrocycle Clustering

open access: yesAngewandte Chemie, EarlyView.
Macrocyclic hosts can remotely rigidify part of a molecule, implying that this part need not be included inside a macrocycle to be stiffened. Here, we show that multiple binding by synthetic hosts CB[7] and CB[8] can selectively rigidify fragments of a tetratopic molecule in water causing a gradual stiffening from the periphery to the core.
Hang Yin   +11 more
wiley   +2 more sources

Regulation of bacterial stringent response by an evolutionarily conserved ribosomal protein L11 methylation

open access: yesmBio
Lysine and arginine methylation is an important regulator of enzyme activity and transcription in eukaryotes. However, little is known about this covalent modification in bacteria. In this work, we investigated the role of methylation in bacteria.
Hanna E. Walukiewicz   +11 more
doaj   +1 more source

Gut Microbiome Pilot Study of Patients With CHARGE Syndrome and Sibling Controls

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Difficulties with feeding and digestion are common in individuals with CHARGE syndrome. Animal models with CHD7 gene variants demonstrate abnormal gut innovation and dysmotility. Our pilot study evaluated whether individuals with CHARGE syndrome have differences in their gut microbiome compared to unaffected siblings.
Emily R. Chedrawe   +5 more
wiley   +1 more source

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong   +7 more
wiley   +1 more source

Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic

open access: yesAngewandte Chemie, EarlyView.
Proteomics and redoxomics are efficient to quantify the effects of bacterial lipopolysaccharide in intestinal epithelial cells (HT29) at the proteome and at the Cys‐redoxome levels. Oxidative stress is the initial trigger of LPS leading to inflammation.
Martha Zoumpoulaki   +14 more
wiley   +2 more sources

Dietary Qiwenghuangbo powder–enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Dietary Qiwenghuangbo powder improved growth performance and intestinal health of weaned piglets, as well as altered microbiota composition as significant enrichment of Limosilactobacillus reuteri. Furthermore, out of three isolated L. reuteri, two strains could alleviate pathogen infection and intestinal inflammation in the colitis models induced by ...
Qian Xu   +11 more
wiley   +1 more source

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