Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins [PDF]
International Journal of Molecular Sciences, 2021 Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis.
Annalisa Pecoraro +3 more
semanticscholar +4 more sources
Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae. [PDF]
PLoS ONE, 2013 During the assembly process of ribosomal subunits, their structural components, the ribosomal RNAs (rRNAs) and the ribosomal proteins (r-proteins) have to join together in a highly dynamic and defined manner to enable the efficient formation of ...
Uli Ohmayer +14 more
doaj +2 more sources
Numerous cultivated and uncultivated viruses encode ribosomal proteins
Nature Communications, 2019 Viruses can encode genes that regulate the host's translational machinery to their advantage. Here, the authors show that viruses encode ribosomal proteins that can be incorporated into the host’s ribosome and may affect translation.
Carolina M. Mizuno +8 more
doaj +2 more sources
Ribosomal proteins in hepatocellular carcinoma: mysterious but promising [PDF]
Cell & BioscienceRibosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors.
Qian Su +6 more
doaj +2 more sources
Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
doaj +3 more sources
ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection
mBio, 2016 Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens.
Liam K. R. Sharkey +2 more
doaj +2 more sources
Proteomics shows that brain metastases of lung adenocarcinoma overexpress ribosomal proteins in response to gamma knife radiosurgery [PDF]
Scientific ReportsGamma knife radiosurgery (GKRS) is recommended as the first-line treatment for brain metastases of lung adenocarcinoma (LUAD) in many guidelines, but its specific mechanism is unclear.
Luqing Tong +8 more
doaj +2 more sources
Yeast Polypeptide Exit Tunnel Ribosomal Proteins L17, L35, and L37 are Necessary to Recruit Late-assembling Factors Required for 27SB Pre-rRNA Processing [PDF]
Nucleic Acids Research, 2012 Ribosome synthesis involves the coordinated folding and processing of pre-rRNAs with assembly of ribosomal proteins. In eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation from the nucleolus to the cytoplasm ...
Babiano González, Reyes +5 more
core +2 more sources
Ribosomal proteins: functions beyond the ribosome. [PDF]
Journal of Molecular Cell Biology, 2015 Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation, their ribosome-independent functions have also been greatly appreciated. Over the past decade, more than a dozen of ribosomal proteins have been found to activate the tumor suppressor p53 pathway in response to ribosomal stress. In addition,
Xiaoping Zhou +4 more
semanticscholar +3 more sources
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Signal Transduction and Targeted Therapy, 2021 Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Jian Kang +5 more
semanticscholar +1 more source