The Influence of Extra-Ribosomal Functions of Eukaryotic Ribosomal Proteins on Viral Infection [PDF]
BiomoleculesThe eukaryotic ribosome is a large ribonucleoprotein complex consisting of four types of ribosomal RNA (rRNA) and approximately 80 ribosomal proteins (RPs), forming the 40S and 60S subunits.
Zhongwei Zhao +8 more
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Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
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Ribosomal proteins produced in excess are degraded by the ubiquitin–proteasome system [PDF]
Molecular Biology of the Cell, 2016 Overexpression of ribosomal proteins in yeast is prevented by ubiquitination of unassembled ribosomal proteins in the nucleus and/or nucleolus followed by proteasome-dependent degradation.
Min-Kyung Sung +4 more
semanticscholar +4 more sources
Ribosome specialization in cancer: a spotlight on ribosomal proteins. [PDF]
NAR CancerAbstractIn the past few decades, our view of ribosomes has changed substantially. Rather than passive machines without significant variability, it is now acknowledged that they are heterogeneous, and have direct regulatory capacity. This ‘ribosome heterogeneity’ comes in many flavors, including in both the RNA and protein components of ribosomes, so ...
Ramalho S, Dopler A, Faller WJ.
europepmc +3 more sources
Numerous cultivated and uncultivated viruses encode ribosomal proteins
Nature Communications, 2019 Viruses can encode genes that regulate the host's translational machinery to their advantage. Here, the authors show that viruses encode ribosomal proteins that can be incorporated into the host’s ribosome and may affect translation.
Carolina M. Mizuno +8 more
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Ribosomal proteins in hepatocellular carcinoma: mysterious but promising [PDF]
Cell & BioscienceRibosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors.
Qian Su +6 more
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ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection
mBio, 2016 Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens.
Liam K. R. Sharkey +2 more
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Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly [PDF]
Science, 2012 Symportin Synchrony Ribosomes, the macromolecular machines responsible for protein synthesis, function in the cytoplasm but are assembled in the nucleus. Ribosomal proteins must be imported into the nucleus, but how this is coordinated with assembly is unclear. Kressler et al.
Kressler, Dieter +11 more
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Proteomics shows that brain metastases of lung adenocarcinoma overexpress ribosomal proteins in response to gamma knife radiosurgery [PDF]
Scientific ReportsGamma knife radiosurgery (GKRS) is recommended as the first-line treatment for brain metastases of lung adenocarcinoma (LUAD) in many guidelines, but its specific mechanism is unclear.
Luqing Tong +8 more
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