Results 191 to 200 of about 5,783,905 (321)

HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia

Cancer Medicine, Volume 11, Issue 24, Page 5050-5065, December 2022., 2022
The aberrant expression pattern and prognostic implications of HIVEP3 in AML were explored and validated based on versatile bioinformatics tools. A LASSO model which combined HIVEP3 with ferroptosis regulators was created to predict the prognosis for AML patients.
Xiaoning Zhang, Xiaoyu Zhang, Kuo Liu, Wenwen Li, Jiazheng Wang, Peng Liu, Wanshan Ma   +6 more
wiley   +1 more source

Decoding the Chemical Language of Ribosomally Synthesized and Post‐Translationally Modified Peptides from the Untapped Archaea Domain

Angewandte Chemie, EarlyView.
Secondary metabolites (SMs) are essential across all life domains, yet those originating from the Archaea domain remain poorly understood. Here, the systematic genome mining and the pioneering heterologous expression of archaeal SMs have revealed the chemical landscape of archaeal lanthipeptides, showing both canonical and non‐canonical forms.
Zhi‐Man Song, Cunlei Cai, Ying Gao, Xiaoqian Lin, Qian Yang, Dengwei Zhang, Gengfan Wu, Haoyu Liang, Qianlin Zhuo, Junliang Zhang, Peiyan Cai, Haibo Jiang, Wenhua Liu, Yong‐Xin Li   +13 more
wiley   +2 more sources

RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5. [PDF]

Proc Natl Acad Sci U S A, 2023
Lee H, Jung JH, Ko HM, Park H, Segall AM, Sheffmaker RL, Wang J, Frey WD, Pham N, Wang Y, Zhang Y, Jackson JG, Zeng SX, Lu H.   +13 more
europepmc   +1 more source

Formylmethionyl‐tRNA Binding Properties of Escherichia coli Ribosomal Protein S1 [PDF]

, 1979
Percy T. LI, Timothy SHEA, Steven ELLIS, Thomas W. Conway   +3 more
openalex   +1 more source

Chemische Proteomik enthüllt menschliche Off‐Targets der durch Fluorchinolone induzierten mitochondrialen Toxizität

Angewandte Chemie, EarlyView.
Ein schematischer Überblick über die schädlichen Wirkungen von Ciprofloxacin im Zusammenhang mit mitochondrialer Toxizität. AIFM1 spielt eine Rolle beim MIA40‐vermittelten Import in das IMS und bei der oxidativen Faltung von kernkodierten Proteinen, einschließlich der Untereinheiten der ETC‐Komplexe I und IV.
Till Reinhardt, Yassmine El Harraoui, Alex Rothemann, Adrian T. Jauch, Sigrid Müller‐Deubert, Martin F. Köllen, Timo Risch, Lianne J. H. C. Jacobs, Rolf Müller, Franziska R. Traube, Denitsa Docheva, Stefan Zahler, Jan Riemer, Nina C. Bach, Stephan A. Sieber   +14 more
wiley   +1 more source

Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile

Cancer Medicine, Volume 11, Issue 24, Page 4900-4912, December 2022., 2022
This study aimed to clarify the prognostic factors for stage IV CRC patients undergoing primary cancer resection but not liver metastasis resection. WES and RNA‐Seq were used to sequence primary cancer tissues of 78 and 84 patients, respectively. Models were established to stratify the prognosis and to predict individual patient prognosis.
Bian Wu, Jinwei Yang, Zhiwei Qin, Hongping Yang, Jingyi Shao, Yun Shang   +5 more
wiley   +1 more source

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells**

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Protein post‐translational modifications allow cells to swiftly adjust activity and localization of proteins. Here, we developed a chemical proteomic approach to determine a protein tyrosination status using an O‐propargyl tyrosine probe. We show that tyrosination modifies previously described alpha‐tubulins with ‐EEY C‐terminal sequence together with ...
Dmytro Makarov, Pavel Kielkowski
wiley   +1 more source

Ribosomal proteins can hold a more accurate record of bacterial thermal adaptation compared to rRNA. [PDF]

Nucleic Acids Res, 2023
van den Elzen A, Helena-Bueno K, Brown CR, Chan LI, Melnikov SV.   +4 more
europepmc   +1 more source

RNA-RNA interactions in the binding site of protein L24 on 23S ribosomal RNA of E. coli II. Sequence analysis of the interacting fragments [PDF]

, 1978
Alain Krol, Mohamed Ali Machatt, Christiane Branlant, J.P. Ebel   +3 more
openalex   +1 more source