Results 21 to 30 of about 5,960,558 (309)

Proteomics shows that brain metastases of lung adenocarcinoma overexpress ribosomal proteins in response to gamma knife radiosurgery [PDF]

open access: yesScientific Reports
Gamma knife radiosurgery (GKRS) is recommended as the first-line treatment for brain metastases of lung adenocarcinoma (LUAD) in many guidelines, but its specific mechanism is unclear.
Luqing Tong   +8 more
doaj   +2 more sources

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

open access: yesmBio, 2016
Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens.
Liam K. R. Sharkey   +2 more
doaj   +2 more sources

Roles of ribosomal proteins in hematologic disorders and cancers: a review

open access: yesEmergency and Critical Care Medicine, 2023
. Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation ...
Jie Wang, Feng Yan
doaj   +1 more source

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

open access: yesSignal Transduction and Targeted Therapy, 2021
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Jian Kang   +5 more
semanticscholar   +1 more source

Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins

open access: yesNature Communications, 2021
Owing to their morphological complexity and dense network connections, neurons modify their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue enriched for dendrites and axons).
Claudia M. Fusco   +9 more
semanticscholar   +1 more source

Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes [PDF]

open access: yesOpen Biology, 2020
Ribosomal proteins are highly conserved, many universally so among organisms. All ribosomal proteins are structural parts of the same molecular machine, the ribosome.
Michael Polymenis
doaj   +1 more source

The roles of ribosomal proteins in nasopharyngeal cancer: culprits, sentinels or both

open access: yesBiomarker Research, 2021
Ribosomal protein genes encode products that are essential for cellular protein biosynthesis and are major components of ribosomes. Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein ...
Edmund Ui-Hang Sim   +2 more
doaj   +1 more source

The Modular Adaptive Ribosome. [PDF]

open access: yesPLoS ONE, 2016
The ribosome is an ancient machine, performing the same function across organisms. Although functionally unitary, recent experiments suggest specialized roles for some ribosomal proteins.
Anupama Yadav   +5 more
doaj   +1 more source

Cotranslational Folding of Proteins on the Ribosome [PDF]

open access: yesBiomolecules, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways. In this review, we summarize the recent examples of how translation affects folding of single-domain,
Marija Liutkute   +2 more
openaire   +4 more sources

Tagging of RPS9 as a tool for ribosome purification and identification of ribosome-associated proteins [PDF]

open access: yesArchives of Biological Sciences, 2021
Ribosomes, the catalytic machinery required for protein synthesis, are comprised of 4 ribosomal RNAs and about 80 ribosomal proteins in mammals. Ribosomes further interact with numerous associated factors that regulate their biogenesis and function.
Jovanović Bogdan   +3 more
doaj   +1 more source

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