Results 41 to 50 of about 421,073 (317)

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora, Baird, Beugnet, Boultwood, Brandenburger, Brenneisen, Browne, Chresta, Christopher G. Proud, Dong, Drygin, Dunlop, Feldman, Fonseca, Fonseca, Fumagalli, Gingras, Grimm, Hannan, Hara, Holzel, Horn, Horos, Huang, Iadevaia, Iadevaia, Jastrzebski, Jefferies, Julien Averous, Killian, Kimball, Kispal, Lam, Le-Bacquer, Lempiainen, Lempiainen, Loreni, Mayer, Mayer, Meyuhas, Miluzio, Montanaro, Oshiro, Patursky-Polischuk, Pearce, Pearson, Peter M. Taylor, Pianese, Popowski, Proud, Redpath, Rodnina, Rohrmoser, Rui Liu, Sancak, Sancak, Sanchez, Sarbassov, Smith, Strezoska, Strezoska, Thoreen, Valentina Iadevaia, Wang, Wang, Willett, Xiao, Yip, Ze Zhang   +68 more
core   +4 more sources

Protein escape at the ribosomal exit tunnel: Effect of the tunnel shape [PDF]

J. Chem. Phys. 153, 045105 (2020), 2020
We study the post-translational escape of nascent proteins at the ribosomal exit tunnel with the consideration of a real shape atomistic tunnel based on the Protein Data Bank (PDB) structure of the large ribosome subunit of archeon Haloarcula marismortui.
arxiv   +1 more source

Alterations in the ribosomal machinery in cancer and hematologic disorders

Journal of Hematology & Oncology, 2012
Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protein translation, ribosomal proteins are also ...
Shenoy Niraj, Kessel Rachel, Bhagat Tushar D, Bhattacharyya Sanchari, Yu Yiting, Mcmahon Christine, Verma Amit   +6 more
doaj   +1 more source

Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system [PDF]

, 2016
Ribosome assembly is an essential process that consumes prodigious quantities of cellular resources. Ribosomal proteins cannot be overproduced in Saccharomyces cerevisiae because the excess proteins are rapidly degraded.
Deshaies, Raymond J., Hess, Sonja, Reitsma, Justin M., Sung, Min-Kyung, Sweredoski, Michael J.   +4 more
core   +2 more sources

Ribosome-Inactivating and Related Proteins [PDF]

Toxins, 2015
Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition,
Schrot, Joachim, Weng, Alexander, Melzig, Matthias F.   +2 more
openaire   +5 more sources

cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins [PDF]

, 2008
mRNA localization is a conserved post-transcriptional process crucial for a variety of systems. Although several mechanisms have been identified, emerging evidence suggests that most transcripts reach the protein functional site by moving along ...
AMORESANO, ANGELA, C. Cirulli, PIETROPAOLO, CONCETTA, PUCCI, PIETRO, RUSSO, ANNAPINA, RUSSO, GIULIA   +5 more
core   +1 more source

Studies on the Coordination of Ribosomal Protein Assembly Events Involved in Processing and Stabilization of Yeast Early Large Ribosomal Subunit Precursors. [PDF]

PLoS ONE, 2015
Cellular production of ribosomes involves the formation of highly defined interactions between ribosomal proteins (r-proteins) and ribosomal RNAs (rRNAs). Moreover in eukaryotic cells, efficient ribosome maturation requires the transient association of a
Uli Ohmayer, Álvaro Gil-Hernández, Martina Sauert, Pilar Martín-Marcos, Mercedes Tamame, Herbert Tschochner, Joachim Griesenbeck, Philipp Milkereit   +7 more
doaj   +1 more source

Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding [PDF]

Physical Biology, 8 (2011) 026005, 2010
Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template. The ribosome is a molecular motor that utilizes the template mRNA strand also as the track. Thus, in
arxiv   +1 more source

Roles of transcriptional and translational control mechanisms in regulation of ribosomal protein synthesis in Escherichia coli [PDF]

, 2017
Bacterial ribosome biogenesis is tightly regulated to match nutritional conditions and to prevent formation of defective ribosomal particles. InEscherichia coli, most ribosomal protein (r-protein) synthesis is coordinated with rRNA synthesis by a ...
Burgos, Hector L, Gourse, Richard L, O\u27Connor, Kevin, Sanchez-Vazquez, Patricia   +3 more
core   +3 more sources

The Arabidopsis cytosolic ribosomal proteome: from form to function

Frontiers in Plant Science, 2013
The cytosolic ribosomal proteome of Arabidopsis thaliana has been studied intensively by a range of proteomics approaches and is now one of the best-characterised eukaryotic ribosomal proteomes.
Adam James Carroll
doaj   +1 more source