Insights into the origin of the nuclear localization signals in conserved ribosomal proteins [PDF]
Nature Communications, 2014 Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly.
S. Melnikov +3 more
semanticscholar +1 more source
Studies on the Coordination of Ribosomal Protein Assembly Events Involved in Processing and Stabilization of Yeast Early Large Ribosomal Subunit Precursors. [PDF]
PLoS ONE, 2015 Cellular production of ribosomes involves the formation of highly defined interactions between ribosomal proteins (r-proteins) and ribosomal RNAs (rRNAs). Moreover in eukaryotic cells, efficient ribosome maturation requires the transient association of a
Uli Ohmayer +7 more
doaj +1 more source
Distribution of dwell times of a ribosome: effects of infidelity, kinetic proofreading and ribosome crowding [PDF]
Physical Biology, 8 (2011) 026005, 2010 Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template. The ribosome is a molecular motor that utilizes the template mRNA strand also as the track. Thus, in
arxiv +1 more source
A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
eLife, 2016 Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1.
semanticscholar +1 more source
The Arabidopsis cytosolic ribosomal proteome: from form to function
Frontiers in Plant Science, 2013 The cytosolic ribosomal proteome of Arabidopsis thaliana has been studied intensively by a range of proteomics approaches and is now one of the best-characterised eukaryotic ribosomal proteomes.
Adam James Carroll
doaj +1 more source
rRNA maturation in yeast cells depleted of large ribosomal subunit proteins. [PDF]
PLoS ONE, 2009 The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S and 5S rRNA and about 46 ribosomal proteins (r-proteins).
Gisela Pöll +7 more
doaj +1 more source
Modelling the effect of ribosome mobility on the rate of protein synthesis [PDF]
Eur. Phys. J. E 44, 19 (2021), 2020 Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally, while unbound ribosomes diffuse in the cytoplasm.
arxiv +1 more source
Ribosomal proteins: functions beyond the ribosome.
Journal of Molecular Cell Biology, 2015 Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation, their ribosome-independent functions have also been greatly appreciated.
Xiaoping Zhou +4 more
semanticscholar +1 more source
Gene length as a regulator for ribosome recruitment and protein synthesis: theoretical insights [PDF]
Scientific Reports 7, Article number: 17409 (2017), 2017 Protein synthesis rates are determined, at the translational level, by properties of the transcript's sequence. The efficiency of an mRNA can be tuned by varying the ribosome binding sites controlling the recruitment of the ribosomes, or the codon usage establishing the speed of protein elongation. In this work we propose transcript length as a further
arxiv +1 more source
Frontiers in Plant Science, 2016 Protein translation is an energy consuming process that has to be fine-tuned at both the cell and organism levels to match the availability of resources.
Thomas Dobrenel +13 more
semanticscholar +1 more source