Results 91 to 100 of about 1,566,471 (276)
Fluctuations in protein synthesis from a single RNA template: stochastic kinetics of ribosomes [PDF]
, 2008 Proteins are polymerized by cyclic machines called ribosome which use their messenger RNA (mRNA) track also as the corresponding template and the process is called translation. We explore, in depth and detail, the stochastic nature of the translation.
arxiv +1 more source
Physical modeling of ribosomes along messenger RNA: estimating kinetic parameters from ribosome profiling experiments using a ballistic model [PDF]
arXiv, 2022 Gene expression consists in the synthesis of proteins from the information encoded on DNA. One of the two main steps of gene expression is the translation of messenger RNA (mRNA) into polypeptide sequences of amino acids. Here, by taking into account mRNA degradation, we model the motion of ribosomes along mRNA with a ballistic model where particles ...
arxiv
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources
RNA: A publication of the RNA Society, 2015 Ribosomal (r)RNAs are extensively modified during ribosome synthesis and their modification is required for the fidelity and efficiency of translation.
Sara Haag, Jens Kretschmer, M. Bohnsack
semanticscholar +1 more source
Ribosome self-assembly leads to overlapping reproduction cycles and increases growth rate [PDF]
arXiv, 2018 In permissive environments, E. coli can double its dry mass every 21 minutes. During this time, ribosomes, RNA polymerases, and the proteome are all doubled. Yet, the question of how to relate bacterial doubling time to other biologically relevant time scales in the growth process remains illusive, due to the complex temporal nesting pattern of these ...
arxiv
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]
, 2012 Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas +47 more
core +4 more sources
PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges
eLife, 2016 Ribosomal RNA transcription mediated by RNA polymerase I represents the rate-limiting step in ribosome biogenesis. In eukaryotic cells, nutrients and growth factors regulate ribosomal RNA transcription through various key factors coupled to cell growth ...
Libin Liu, Paul F Pilch
doaj +1 more source
arXiv, 2012 The simplest possible beginning of abiogenesis has been a riddle from the last century, which is most successfully solved by the Lipid World hypothesis. However, origin of the next stages of evolution starting form lipids is still in dark. We propose a 'Lipid-RNA World Scenario' based on the assumption that modern stable lipid-RNA interactions are ...
arxiv
Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America, 1978 The complete nucleotide sequence of the 16S RNA gene from the rrnB cistron of Escherichia coli has been determined by using three rapid DNA sequencing methods.
J. Brosius +3 more
semanticscholar +1 more source
Mammalian Ribosomal Precursor RNA [PDF]
, 1974 Both 18s and 28s ribosomal RNA in HeLa cells are transcribed in the nucleolus within a single large precursor RNA molecule (45S RNA) which is believed to contain, in addition to the ribosomal sequences, extensive non-ribosomal regions termed "transcribed
Robertson, James Searl
core