Results 71 to 80 of about 1,110,020 (298)

Ancestral Interactions of Ribosomal RNA and Ribosomal Proteins [PDF]

Biophysical Journal, 2017
We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components.
Kathryn A, Lanier, Poorna, Roy, Dana M, Schneider, Loren Dean, Williams   +3 more
openaire   +2 more sources

Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]

, 2010
The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

Ribosomal RNA Transcription Regulation in Breast Cancer

, 2021
Ribosome biogenesis is a complex process that is responsible for the formation of ribosomes and ultimately global protein synthesis. The first step in this process is the synthesis of the ribosomal RNA in the nucleolus, transcribed by RNA Polymerase I ...
Amber F. Buhagiar, Susan J. Baserga, Yan Cheng, Cecelia M. Harold   +3 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Genetic diversity of Trichoderma spp. isolated from alkaline pistachio soils using morphological and molecular characteristics [PDF]

Journal of Advances in Plant Protection
The genetic diversity of Trichoderma species isolated from pistachio soils in Kerman Province was investigated. A total of 131 isolates were obtained and identified at the species level by analyzing their morphological characters.
Hossein Alaei, Fahimeh Mirkhani, Amirhossein Mohammadi, Masoumeh Haghdel   +3 more
doaj   +1 more source

Structural basis of ribosomal RNA transcription regulation

Nature Communications, 2021
Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key ...
Yeonoh Shin, M. Zuhaib Qayyum, Danil Pupov, Daria Esyunina, Andrey Kulbachinskiy, Katsuhiko S. Murakami   +5 more
doaj   +1 more source

The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14 [PDF]

, 2005
One of the proteins identified as being involved in ribosome biogenesis by high-throughput studies, a putative P-loop-type kinase termed Fap7 (YDL166c), was shown to be required for the conversion of 20S pre-rRNA to 18S rRNA.
Nandineni, Madhusudan R, Granneman, Sander; id_orcid, Baserga, Susan J   +2 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source