Results 91 to 100 of about 342,035 (308)

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]

, 2002
Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Tollervey, D, Hurt, E, Pierre-Emmanuel Gleizes, Elisabeth Petfalski, Ed Hurt, Olivier Gadal, David Tollervey, Gleizes, P E, Strauss, D, Gas, N, Daniela Strauss, Gadal, O, Petfalski, E, Nicole Gas   +13 more
core   +1 more source

Methylation of Ribosomal RNA: A Mitochondrial Perspective

Frontiers in Genetics, 2020
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitochondrial ribosomes (mitoribosomes) are responsible for the synthesis of 13
M. Isabel G. Lopez Sanchez, M. Isabel G. Lopez Sanchez, Miriam Cipullo, Miriam Cipullo, Shreekara Gopalakrishna, Shreekara Gopalakrishna, Anas Khawaja, Anas Khawaja, Joanna Rorbach, Joanna Rorbach   +9 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

The Protist Ribosomal Reference database (PR2): a catalog of unicellular eukaryote Small Sub-Unit rRNA sequences with curated taxonomy [PDF]

, 2012
The interrogation of genetic markers in environmental meta-barcoding studies is currently seriously hindered by the lack of taxonomically curated reference data sets for the targeted genes.
Probert, Ian, Dolan, John R., Kooistra, Wiebe H.C.F., Guillou, Laure, Vaulot, Daniel, Campo, Javier, Del, Morard, Raphael, Bass, David, Logares, Ramiro, Montresor, Marina, del Campo, Javier, Lara, Enrique, Berney, Cédric, Zimmermann, Pascal, Burgaud, Gaétan, Pawlowski, Jan, Campo, Javier,, Bachar, Dipankar, Boutte, Christophe, Bittner, Lucie, Christen, Richard, Mahe, Frédéric, Dunthorn, Micah, Kooistra, Wiebe H. C. F., ,, Siano, Raffaele, Stoeck, Thorsten, Le Bescot, Noan, Audic, Stéphane, Decelle, Johan, Not, Fabrice, Massana, Ramon, de Vargas, Colomban, Sauvadet, Anne-Laure, Edvardsen, Bente, Holzmann, Maria   +35 more
core   +1 more source

16S ribosomal RNA gene-based metagenomics: A review

Biomedical Research Journal, 2020
With the advent of contemporary molecular tools, the conventional microbiological isolation, enrichment techniques, and approaches have changed considerably.
Asmita Kamble, Shriya Sawant, Harinder Singh   +2 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Cytoplasmic RNA-dependent RNA-synthesis in maturing chicken erythrocytes. [PDF]

, 1976
Includes bibliographical references.An RNA-dependent RNA polymerase from ribosomes of maturing chicken erythrocytes was investigated. Concurrent with an increase in globin and RNA synthesis during phenylhydrazine induced anaemia, the total and specific ...
Boyd, Malcolm Charles David
core  

The Beak of Eukaryotic Ribosomes: Life, Work and Miracles

Biomolecules
Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of tentacle-like projections, which are frequently made up of ribosomal RNA expansion segments and N- or C-terminal extensions of ribosomal ...
Sara Martín-Villanueva, Carla V. Galmozzi, Carmen Ruger-Herreros, Dieter Kressler, Jesús de la Cruz   +4 more
doaj   +1 more source