Results 121 to 130 of about 3,389,293 (247)

Enhanced cytotoxic activity of a bifunctional chimeric protein containing a type 1 ribosome-inactivating protein and a serine protease inhibitor

, 2012
Both ribosome-inactivating proteins (RIPs) and plant proteinase inhibitors, belong to protein families known to regulate cellular homeostasis and likely involved in plant defense.
Francesca Tedeschi, PIZZO, ELIODORO, Augusto Parente, Rachele Tamburino, Elia Poerio, Anna G. Ficca, Antimo Di Maro, SARCINELLI, CARMEN   +7 more
core   +2 more sources

A Resources Investigation on the Content of Curcin in Jatropha Seed Endosperm Collected from Six Location in Sichuan, Yunnan and Hainan Province

四川大学学报. 自然科学版, 2017
The ribosome inactivating protein (curcin) expressed in Jatropha curcas L provides advantages, comparing to prokaryotic expression systems, on the study of protein folding and modification for better development and application of the protein. Therefore,
YANG Qian, JI Rou-Feng, LI Chen-Yang, ZHANG Yang-Xue, YU Hong-Wu, TAO Cheng-Qiu, CHEN Fang, XU Ying   +7 more
doaj  

Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models

ADMET and DMPK
Background and purpose: Trichosanthin (TCS) is a plant-based ribosome-inactivating protein exhibiting a range of pharmacological properties, including abortifacient and anticancer.
Yan Zhou, Maoxin Ran, Wenying Shan, Kaifang Wang, Ou Sha, Kin Tam   +5 more
doaj   +1 more source

Plant-Derived Type I Ribosome Inactivating Protein-Based Targeted Toxins: A Review of the Clinical Experience. [PDF]

Toxins (Basel), 2022
Flavell DJ, Flavell SU.
europepmc   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Analysis of the Structure of SaHPF Staphylococcus aureus Protein [PDF]

Учёные записки Казанского университета: Серия Естественные науки, 2016
SaHPF (Staphylococcus aureus hibernation promoting factor) is the ribosome inactivating protein of the bacterium Staphylococcus aureus. The structure of this protein has been predicted using bioinformatics methods and represented by two domains and a ...
R.Kh. Ayupov, N.I. Akberova
doaj  

WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer

Cancer Science, EarlyView.
WDR12 promotes glucose metabolism and tumor growth in GC. Mechanistically, WDR12 interacts with TDP43 and appears to enhance PFKFB4 expression, thereby promoting glucose metabolism. ABSTRACT Metabolic reprogramming is a hallmark of gastric cancer (GC); however, the role of transcriptional regulators in modulating glycolysis remains incompletely ...
Rutong Zhang, Dehua Liu, Xiaoxi Feng, Aoxing Cheng, Zhenye Yang, Kaiguang Zhang   +5 more
wiley   +1 more source

Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells. [PDF]

Toxins (Basel), 2021
Rotondo R, Ragucci S, Castaldo S, Oliva MA, Landi N, Pedone PV, Arcella A, Di Maro A.   +7 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source