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Ribosome-Inactivating Proteins in Cereals
2010Plants constitutively accumulate proteins that are either toxic or inhibitory against pathogens, including ribosome-inactivating proteins (RIPs) and N-glycosidases that depurinate the universally conserved α-sarcin loop of large rRNAs. Cereal RIPs share a high similarity with all the other RIPs; however, they retain characteristic features forming a ...
Carlotta Balconi +2 more
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Isolation and Purification of Ribosome-Inactivating Proteins
2005Ribosome-inactivating proteins (RIPs) are cytotoxic N-glycosidases identified in plants, fungi, and bacteria. RIPs inhibit protein synthesis by virtue of their enzymatic activity, selectively cleaving a specific adenine residue from a highly conserved, surface-exposed, stem-loop (S/R loop) structure in the 28S rRNA of ribosomes.
Sang-Wook, Park +3 more
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Ribosome inactivating proteins of plants.
Seminars in cell biology, 1992Many plant tissues produce single chain proteins which can enzymatically remove a specific adenine residue from ribosomal RNA. Although these proteins are potently toxic to isolated ribosomes, they are non-toxic to intact cells, being unable to gain access to their ribosomal substrate.
J M, Lord, M R, Hartley, L M, Roberts
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Immunotoxins containing single chain ribosome-inactivating proteins
1988We have summarized what is currently known about the distribution, biological role, and the mechanism of action of the single chain ribosome-inactivating proteins and described the purification of one of them, gelonin, as an example. ITs have been made with several of these proteins and, depending upon the antibody used for conjugation, these ...
J M, Lambert +4 more
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Virus resistance mediated by ribosome inactivating proteins
2000Publisher Summary This chapter describes recent advances in understanding the structure and function of ribosome inactivating proteins (RIPs) and the mechanism of their antiviral activity. RIPs are widely distributed among plants, fungi, and bacteria.
P, Wang, N E, Tumer
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Ribosome-inactivating proteins: From toxins to useful proteins
Toxicon, 2013Ribosome-inactivating proteins (RIPs) either single-chain (type 1) or two-chain (type 2) are frequent in plants, often in multiple forms. They are RNA N-glycosidases, have antiviral, antifungal and insecticidal activity. Their expression in plants is increased under stressful conditions.
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Sambucus Ribosome-Inactivating Proteins and Lectins
2010Plant ribosome-inactivating proteins (RIPs) are inhibitors with RNA-N-glycosidase activity that irreversibly inactivate eukaryotic ribosomes, thereby impairing protein synthesis. In recent years, more than 40 RIPs and lectins belonging to the Sambucus genus have been isolated and characterized to varying degrees.
José Miguel Ferreras +4 more
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Ribosome-Inactivating Proteins from Abrus pulchellus
2010Pulchellins are highly toxic type 2 ribosome-inactivating proteins (RIPs) expressed in the seeds of Abrus pulchellus tenuiflorus. Four pulchellin isoforms have been characterized, allowing their classification into two subgroups based on the toxicity levels and sugar-binding specificity.
Ana Paula Ulian Araújo +2 more
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Biotechnology of ribosome-inactivating proteins
1993See the proper ...
SANITA' di TOPPI, LUIGI, SPANO' L.
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