Leveraging paired germline and somatic analysis to improve the classification of DDX41 variants
Summary Constitutional pathogenic variants in DDX41 predispose to myelodysplasia and acute myeloid leukaemia. Acquisition of subsequent somatic hits in the second allele is frequent, with notable recurrent variants at key hotspots. Sequencing of Deoxyribonucleic acid from blood/marrow of 239 patients with suspected/confirmed haematological malignancies
Andrew George +13 more
wiley +1 more source
Emerging Technologies for Biobutanol Production via Syngas Fermentation
Biobutanol production from syngas is promising but limited by microbial energy conservation and gas–liquid mass transfer. This review integrates advances in cultivation control and bioreactor engineering with next‐generation biological tools including metabolic rewiring, co‐cultivation and chain elongation, and electro‐fermentation to enable carbon ...
Xuemei Wang +3 more
wiley +1 more source
Summary Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the acclimation of Arabidopsis thaliana quantitative immune responses against the fungal pathogen Sclerotinia sclerotiorum to daily environmental ...
Marie Didelon +6 more
wiley +1 more source
The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway. [PDF]
Yang D +7 more
europepmc +1 more source
Purification of a ribosome-inactivating protein with antioxidation and root developer potencies from Celosia plumosa. [PDF]
Gholizadeh A.
europepmc +1 more source
Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways. [PDF]
Chen YJ +10 more
europepmc +1 more source
Dual targeting NG2 and GD3A using Mab-Zap immunotoxin results in reduced glioma cell viability in vitro [PDF]
Ashkan, Keyoumars +4 more
core +1 more source
SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. [PDF]
Roy S +9 more
europepmc +1 more source
Optimization of EnBase Fed-Batch Cultivation to Improve Soluble Fraction Ratio of α-Luffin Ribosome Inactivating Protein. [PDF]
Barkhordari F +4 more
europepmc +1 more source

