Results 151 to 160 of about 3,389,293 (247)

NMR‐Guided Fragment Screening Identifies Privileged Noncanonical Amino Acids for mRNA Display

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A strategy is reported to prescreen and prioritize noncanonical amino acids as fragments prior to their use in mRNA display peptide libraries. Using MDM2 as a target, two ncAAs that bind to the Trp binding pocket in MDM2 are found by protein‐observed NMR.
Abdul J. Castillo, Clark A. Jones, Alba C. Dutra, Chelsea A. Makovsky, Sandeep Lohan, Bipasana Shakya, Sara H. Walters, Brian Fuglestad, Matthew C. T. Hartman   +8 more
wiley   +1 more source

Mayahuelin, a Type I Ribosome Inactivating Protein: Characterization, Evolution, and Utilization in Phylogenetic Analyses of Agave. [PDF]

Front Plant Sci, 2020
Lledías F, Gutiérrez J, Martínez-Hernández A, García-Mendoza A, Sosa E, Hernández-Bermúdez F, Dinkova TD, Reyes S, Cassab GI, Nieto-Sotelo J.   +9 more
europepmc   +1 more source

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
METTL18 is essential for histidine Nτ‐methylation of proteins, normal embryonic development, iron and lipid metabolism, and hormone signaling pathways that support postnatal growth in mice. The main points of this study are as follows: First, mouse METTL18 catalyzes histidine Nτ‐methylation. Next, Mettl18 KO embryos are significantly smaller than their
Fumiya Kasai, Jun‐Dal Kim, Koichiro Kako, Naoto Muromachi, Takeru Saito, Yao Yuan, Hayase Mizukami, Nana Kishikawa, Kanako Nakamura, Kaori Motomura, Hiroaki Daitoku, Yuuki Imai, Sho Sekiguchi, Kazuhiko Horiguchi, Satoshi Narumi, Masanobu Yamada, Akiyoshi Fukamizu   +16 more
wiley   +1 more source

Identification and cloning of Ribosome-Inactivating Protein (RIP) genes in selected species of the Euphorbiaceae family

, 2010
Ribosome-inactivating proteins (RIP) inhibit protein synthesis in eukaryotic cells by catalytically damaging ribosomes. They are most abundant in a few plant families which include the Euphorbiaceae family.
MARICEL, CORPUZ
core   +1 more source

Molecular cloning and in-depth bioinformatics analysis of type II ribosome-inactivating protein isolated from Sambucus ebulus. [PDF]

Saudi J Biol Sci, 2020
Rezaei-Moshaei M, Bandehagh A, Dehestani A, Pakdin-Parizi A, Golkar M.   +4 more
europepmc   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, Volume 13, Issue 51, 14 September 2026.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Use of the “Ru‐1O2‐Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Advanced Science, Volume 13, Issue 52, 18 September 2026.
ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun, Kaihong Wang, Haifu Sun, Kemei Tao, Xiang Li, Xiuhua Zhao, Shuang Qiu   +6 more
wiley   +1 more source

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source

MAP30, a type Ⅰ ribosome-inactivating protein, inhibits hepatocellular carcinoma by inducing apoptosis through mitochondria. [PDF]

Medicine (Baltimore)
Yang D, Peng D, Jia D, Zhou Y, Li H, Jiang Z, Meng Y.   +6 more
europepmc   +1 more source

The Molecular Architecture of Somatic Spines of the Lateral Septum

Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.
Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker, Erich Weisheim, Michaela Schweizer, Undine Schneeweiß, Maximilian Borgmeyer, Michael Brecht, Marina Mikhaylova   +6 more
wiley   +1 more source