Results 201 to 210 of about 25,832 (246)

Ribosome-inactivating proteins

Toxicon, 1997
Abstract Ribosome-inactivating proteins (RIPs, review by Barbieri et a/. 1993) are a class of proteins present in various tissues of several plants which inactivate mammalian ribosomes and, with less activity and to variable extent, plant, fungal, and bacterial ribosomes. They are enzymes, N-glycosidases, which release adenine from rRNA.
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Ribosome-inactivating proteins in plant biology

Planta, 2004
Ribosome-inactivating proteins (RIPs) are a group of cytotoxic Af-glycosidases that specifically cleave nucleo tide N-C glycosidic bonds. RIPs have been classified into three types: type I is composed of a single polypeptide chain, whereas type II is a heterodimer consisting of an A chain, functionally equivalent to a type I, which is attached to a ...
Sang-Wook, Park, Ramarao, Vepachedu, Neelam, Sharma, Jorge M, Vivanco   +3 more
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Ribosome-inactivating proteins: progress and problems

Cellular and Molecular Life Sciences, 2006
Ribosome-inactivating proteins (RIPs), mostly from plants, are enzymes which depurinate rRNA, thus inhibiting protein synthesis. They also depurinate other polynucleotide substrates. The biological activity of RIPs is not completely clarified, and sometimes independent of the inhibition of protein synthesis. There are differences in the cytotoxicity of
STIRPE, FIORENZO, BATTELLI, MARIA GIULIA
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Ribosome-inactivating proteins in edible plants and purification and characterization of a new ribosome-inactivating protein from Cucurbita moschata

Biochimica Et Biophysica Acta - General Subjects, 2006
The basic protein fraction of tissue extracts from 40 edible plants inhibited cell-free protein synthesis and released adenine from herring sperm DNA, thus having adenine glycosylase activity. This suggested the presence of ribosome-inactivating proteins (RIPs) in the plant extracts.
Letizia Polito, Andrea Bolognesi, Emanuele Pelosi   +2 more
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Occupational sensitization to ribosome‐inactivating proteins in researchers

Clinical & Experimental Allergy, 2005
SummaryBackground Ribosome‐inactivating proteins (RIPs) are expressed in many plants. Because of their anti‐infectious and anti‐proliferative effects, intensive research is going on for applying these toxins in therapy against viral infections or malignancies.
K, Szalai, I, Schöll, E, Förster-Waldl, L, Polito, A, Bolognesi, E, Untersmayr, A B, Riemer, G, Boltz-Nitulescu, F, Stirpe, E, Jensen-Jarolim   +9 more
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Isolation and Purification of Ribosome-Inactivating Proteins

2005
Ribosome-inactivating proteins (RIPs) are cytotoxic N-glycosidases identified in plants, fungi, and bacteria. RIPs inhibit protein synthesis by virtue of their enzymatic activity, selectively cleaving a specific adenine residue from a highly conserved, surface-exposed, stem-loop (S/R loop) structure in the 28S rRNA of ribosomes.
Sang-Wook, Park, Balakrishnan, Prithiviraj, Ramarao, Vepachedu, Jorge M, Vivanco   +3 more
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The Genetics and Properties of Cereal Ribosome-Inactivating Proteins

Mini-Reviews in Medicinal Chemistry, 2004
Plants contain proteins that are capable of inactivating ribosomes, commonly referred to as Ribosome Inactivating Proteins (RIPs). These particular plant proteins have received attention in biological and biomedical research because of their unique biological activities towards animals and human cells as cell-killing agents.
Mario, Motto, Elisabetta, Lupotto
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Comparison of ribosome-inactivating proteins in the induction of apoptosis

Toxicology Letters, 1997
The aim of this study was to evaluate the ability of verocytotoxin-1 (VT1), VT1 B chain alone, ricin and a hybrid toxin (RASTA2) consisting of ricin A chain linked to VT1 B chain to inhibit protein synthesis and to induce apoptosis. The lethal effects of the toxins were compared using vero cells (originating from green African monkey kidney tissue). As
J M, Williams, N, Lea, J M, Lord, L M, Roberts, D V, Milford, C M, Taylor   +5 more
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On the Distribution of Ribosome-Inactivating Proteins amongst Plants

Journal of Natural Products, 1985
The extracts from various parts (mostly seeds) of 56 different plants were examined for inhibition of protein synthesis by a rabbit reticulocyte lysate. Most extracts inhibited protein synthesis with an ID50 (concentration giving 50% inhibition) of 100 micrograms extract protein per ml, or less.
A, Gasperi-Campani, L, Barbieri, M G, Battelli, F, Stirpe   +3 more
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Ribosome Inactivating Proteins from an evolutionary perspective

Toxicon, 2017
Ribosome Inactivating Proteins (RIPs) are rRNA N-glycosidases that inhibit protein synthesis through the elimination of a single adenine residue from 28S rRNA. Many of these toxins have been characterized in depth from a biochemical and molecular point of view.
Walter Jesús, Lapadula, Maximiliano Juri, Ayub   +1 more
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