Results 211 to 220 of about 3,389,293 (247)

Occupational sensitization to ribosome‐inactivating proteins in researchers

Clinical & Experimental Allergy, 2005
SummaryBackground Ribosome‐inactivating proteins (RIPs) are expressed in many plants. Because of their anti‐infectious and anti‐proliferative effects, intensive research is going on for applying these toxins in therapy against viral infections or malignancies.
K, Szalai, I, Schöll, E, Förster-Waldl, L, Polito, A, Bolognesi, E, Untersmayr, A B, Riemer, G, Boltz-Nitulescu, F, Stirpe, E, Jensen-Jarolim   +9 more
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Isolation and Purification of Ribosome-Inactivating Proteins

2005
Ribosome-inactivating proteins (RIPs) are cytotoxic N-glycosidases identified in plants, fungi, and bacteria. RIPs inhibit protein synthesis by virtue of their enzymatic activity, selectively cleaving a specific adenine residue from a highly conserved, surface-exposed, stem-loop (S/R loop) structure in the 28S rRNA of ribosomes.
Sang-Wook, Park, Balakrishnan, Prithiviraj, Ramarao, Vepachedu, Jorge M, Vivanco   +3 more
openaire   +2 more sources

The Genetics and Properties of Cereal Ribosome-Inactivating Proteins

Mini-Reviews in Medicinal Chemistry, 2004
Plants contain proteins that are capable of inactivating ribosomes, commonly referred to as Ribosome Inactivating Proteins (RIPs). These particular plant proteins have received attention in biological and biomedical research because of their unique biological activities towards animals and human cells as cell-killing agents.
Mario, Motto, Elisabetta, Lupotto
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Comparison of ribosome-inactivating proteins in the induction of apoptosis

Toxicology Letters, 1997
The aim of this study was to evaluate the ability of verocytotoxin-1 (VT1), VT1 B chain alone, ricin and a hybrid toxin (RASTA2) consisting of ricin A chain linked to VT1 B chain to inhibit protein synthesis and to induce apoptosis. The lethal effects of the toxins were compared using vero cells (originating from green African monkey kidney tissue). As
J M, Williams, N, Lea, J M, Lord, L M, Roberts, D V, Milford, C M, Taylor   +5 more
openaire   +2 more sources

On the Distribution of Ribosome-Inactivating Proteins amongst Plants

Journal of Natural Products, 1985
The extracts from various parts (mostly seeds) of 56 different plants were examined for inhibition of protein synthesis by a rabbit reticulocyte lysate. Most extracts inhibited protein synthesis with an ID50 (concentration giving 50% inhibition) of 100 micrograms extract protein per ml, or less.
A, Gasperi-Campani, L, Barbieri, M G, Battelli, F, Stirpe   +3 more
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Ribosome Inactivating Proteins from an evolutionary perspective

Toxicon, 2017
Ribosome Inactivating Proteins (RIPs) are rRNA N-glycosidases that inhibit protein synthesis through the elimination of a single adenine residue from 28S rRNA. Many of these toxins have been characterized in depth from a biochemical and molecular point of view.
Walter Jesús, Lapadula, Maximiliano Juri, Ayub   +1 more
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Ribosome Inactivating Proteins and Apoptosis

2010
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases which potently inhibit translation by inactivating ribosomes. RIPs have also been shown to possess the ability to induce apoptosis. A number of RIPs from different sources have been used to study the mechanism of apoptosis induction.
Deepa Sikriwal, Janendra K. Batra
openaire   +1 more source

Recent Progress in Research on Ribosome Inactivating Proteins

Current Protein and Peptide Science, 2009
The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs) including isolation and characterization of new RIPs, studies on the crystal structures and mechanisms of actions of RIPs, the use of saporin-based neurotoxins to selectively lesion cholinergic neurons in neuroscience research, and the use of RIP-based ...
T B, Ng, Jack Ho, Wong, Hexiang, Wang
openaire   +2 more sources

Ribosome-Inactivating Proteins in Cereals

2010
Plants constitutively accumulate proteins that are either toxic or inhibitory against pathogens, including ribosome-inactivating proteins (RIPs) and N-glycosidases that depurinate the universally conserved α-sarcin loop of large rRNAs. Cereal RIPs share a high similarity with all the other RIPs; however, they retain characteristic features forming a ...
Carlotta Balconi, Chiara Lanzanova, Mario Motto   +2 more
openaire   +1 more source

Antiviral Activity Of Ribosome Inactivating Proteins In Medicine

Mini-Reviews in Medicinal Chemistry, 2004
Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs.
Bijal A, Parikh, Nilgun E, Tumer
openaire   +2 more sources