Results 101 to 110 of about 1,934 (175)

Saporin-S6: A Useful Tool in Cancer Therapy

Toxins, 2013
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it ...
Letizia Polito, Massimo Bortolotti, Daniele Mercatelli, Maria Giulia Battelli, Andrea Bolognesi   +4 more
doaj   +1 more source

Ricin and Ricin-Containing Immunotoxins: Insights into Intracellular Transport and Mechanism of action in Vitro

Antibodies, 2013
Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska-Wojewódzka, Kirsten Sandvig   +1 more
doaj   +1 more source

Phytochemical Screening and Pharmacological Activity of Seed Extract and Seed Oil of Lagenaria siceraria.

Journal of Basic and Applied Research in Biomedicine, 2022
The present study includes detailed aspects of seeds of Lagenaria siceraria (Mol.) Standley used as medicinal plant. The Lagenaria seeds contain steroidal moieties like avenasterol, codisterol, elesterol, isofucasterol, stigmasterol and Legenin, a ...
Pragya Nigam, Bina Gidwani, Chanchal Kaur, Hemant Dhongade   +3 more
doaj  

CYTOTOXICITY IDENTIFICATION OF THE SUPERNATANT OF Manihot esculenta Crantz RHIZOME AS RIBOSOME-INACTIVATING PROTEIN TO NORMAL CELL

Indonesian Journal of Chemistry, 2010
The supernatant of Manihot esculenta Crantz rhizome has been used as an alternative remedy of infectious and cancer in Jogjakarta. Cytotoxicity assay showed that  Manihot esculenta Crantz supernatant had cytotoxic effect to cancer cell line, namely ...
Endang Astuti, Sabirin Matsjeh, Winarto Haryadi, Deni Pranowo, Nuning Sri Mulatsih   +4 more
doaj   +1 more source

Possible defense molecules in barley [PDF]

, 1992
The recent development of refined molecular tools to study gene structure and function, as well as the availability of genetic transformation methods for all kinds of organisms, including plants, has lent new vigor to the investigation of plant defense ...
García Olmedo, Francisco
core  

Generality of toxins in defensive symbiosis: Ribosome-inactivating proteins and defense against parasitic wasps in Drosophila.

PLoS Pathogens, 2017
While it has become increasingly clear that multicellular organisms often harbor microbial symbionts that protect their hosts against natural enemies, the mechanistic underpinnings underlying most defensive symbioses are largely unknown.
Matthew J Ballinger, Steve J Perlman
doaj   +1 more source

Potensi Ekstrak Etanol Daun Keladi Tikus (Typhonium Flagelliforme Lodd.) sebagai Induktor Apoptosis Sel Kanker Lidah Manusia (SP-C1) [PDF]

, 2012
Typhonium flagelliforme Lodd has been used traditionally to cure breast cancer, lung, colon, rectum, liver, prostate, kidney, cervix, throat, bone, brain, spleen, bladder, leukimia and pancreas cancer.
Medawati, A. (Ana), Rahmawati, A. D. (Atiek), Ridlo, H. R. (Himmaturojuli), Supriatno, S. (Supriatno)   +3 more
core   +3 more sources

Analysis of castor bean ribosome-inactivating proteins and their gene expression during seed development

Genetics and Molecular Biology, 2013
Ribosome-inactivating proteins (RIPs) are enzymes that inhibit protein synthesis after depurination of a specific adenine in rRNA. The RIP family members are classified as type I RIPs that contain an RNA-N-glycosidase domain and type II RIPs that contain
Guilherme Loss-Morais, Andreia Carina Turchetto-Zolet, Matheus Etges, Alexandro Cagliari, Ana Paula Körbes, Felipe dos Santos Maraschin, Márcia Margis-Pinheiro, Rogério Margis   +7 more
doaj  

A case of accidental Ricin poisoning [PDF]

, 2004
A case report of accidental, mild ricin poisoning by ingestion of ten Castor beans by a 70 year old man. The clinical presentation is followed by a discussion about the toxicity of ricin, its use and misuse and the contrast between the toxicity of pure ...
Cachia, Mario J., Despott, Edward
core  

Synthesis of biologically active Shiga toxins in cell-free systems

Scientific Reports
Shiga toxins (Stx) produced by pathogenic bacteria can cause mild to severe diseases in humans. Thus, the analysis of such toxins is of utmost importance.
Franziska Ramm, Danny Kaser, Irina König, Juliane Fellendorf, Dana Wenzel, Anne Zemella, Panagiotis Papatheodorou, Holger Barth, Herbert Schmidt   +8 more
doaj   +1 more source