Antifungal Activity of Ribosome-Inactivating Proteins. [PDF]
Toxins (Basel)The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly.
Iglesias R +3 more
europepmc +4 more sources
Ribosome-Inactivating and Related Proteins [PDF]
Toxins, 2015 Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs.
Alexander Weng, Matthias F Melzig
exaly +5 more sources
Elderberries: a source of ribosome-inactivating proteins with lectin activity. [PDF]
Molecules, 2015 Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied.
Tejero J +7 more
europepmc +7 more sources
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties. [PDF]
Toxins (Basel), 2020 Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Lu JQ, Zhu ZN, Zheng YT, Shaw PC.
europepmc +2 more sources
Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine. [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their
Polito L +4 more
europepmc +2 more sources
Evolution of plant ribosome-inactivating proteins [PDF]
, 2010 This contribution presents an updated analysis of the evolution of ribosome-inactivating proteins (RIPs) in plants. All evidence suggests that an ancestor of modern seed plants developed the RIP domain at least 300 million years ago.
Peumans, Willy J, Van Damme, Els
core +2 more sources
The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations. [PDF]
Toxins (Basel), 2017 Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a century ago. They continue to fascinate scientists and the public due to their very high activity and long-term stability which might find useful applications in the ...
Rust A +3 more
europepmc +2 more sources
Ribosome-Inactivating Proteins of Bougainvillea glabra Uncovered Polymorphism and Active Site Divergence. [PDF]
Toxins (Basel), 2021 Ribosome-inactivating proteins (RIPs) are toxic proteins that can inhibit protein synthesis. RIPs purified from Bougainvillea have low nonspecific toxicity, showing promise for processing applications in the agricultural and medical fields.
Lin Y +6 more
europepmc +2 more sources
Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins. [PDF]
Toxins (Basel), 2018 Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA.
Zhou Y, Li XP, Kahn JN, Tumer NE.
europepmc +2 more sources
Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins. [PDF]
Bio Protoc, 2017 Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
Iglesias R, Citores L, Ferreras JM.
europepmc +2 more sources