Molecularly imprinted polymers for protome analysis [PDF]
Fast and efficient methods for the detection of insurgence and progression of diseases are at the basis of modern diagnostics and medicine. In this concern, biomarkers represent a powerful diagnostic tool, as their expression profiles well correlate ...
Bonini, Francesca
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Ribosome Inactivating Proteins and Apoptosis
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases which potently inhibit translation by inactivating ribosomes. RIPs have also been shown to possess the ability to induce apoptosis.
Batra, Janendra K. +3 more
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Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a targeting domain coupled chemically or genetically to a proteinaceous toxin payload.
David J. Flavell, Sopsamorn U. Flavell
doaj +1 more source
Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities. [PDF]
Ribosome-inactivating proteins (RIPs) inactivate prokaryotic or eukaryotic ribosomes by removing a single adenine in the large ribosomal RNA. Here we show maize RIP (MOD), an atypical RIP with an internal inactivation loop, interacts with the ribosomal ...
Yuen-Ting Wong +5 more
doaj +1 more source
Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan +6 more
doaj +1 more source
Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature.
Begoña Barriuso +7 more
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Plant Toxins as Potential Alternatives to Botulinum Toxin for Eye-Movement Disorder Therapy
The most successful alternative to traditional surgery for ocular muscle spasm treatment is the intramuscular injection of botulinum toxin (BTX), which allows the maintenance of the muscle dynamics and the absence of scars.
Massimo Bortolotti +5 more
doaj +1 more source
Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells
Flavonoids such as naringenin, quercetin, and naringin are known to exhibit anticancer properties. In this study, we examined the effects of these flavonoids on cell viability and apoptotic pathways of cancer cells, either singly or in combination with ...
Parminder K. Ajji +3 more
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Effect of transgenic tobacco plant, Nicotiana tabacum expressing ribosome inactivating gene isolated from the bulbs of Dutch iris, Iris hollandica on biological parameters of Myzus nicotianae (Hem.: Aphididea) and Spodoptera exigua (Lep.: Noctuidae) [PDF]
The use of modified crop plants through gene transfer between different plant species plays an important role in pest control programs. We have investigated the insecticidal properties of two lines of tobacco transgenic plant consisting of IRIP ...
Sh. Shahidi-Noghabi
doaj
Ribosome-inactivating Proteins from Phytolaccaceae
The plant family Phytolaccaceae is a rich source of ribosome-inactivating proteins (RIPs), including the first characterized non-toxic type 1 RIP, pokeweed antiviral protein from the plant Phytolacca americana. The antiviral property is important because
DI MARO, Antimo +9 more
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