Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins [PDF]
Bio-Protocol, 2017 Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras +2 more
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Ribosome inactivating proteins and apoptosis [PDF]
FEBS Letters, 2005 Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis.
Karande, Anjali A. +10 more
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Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases [PDF]
Toxins, 2018 Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae, and bacteria. RIP activities have also been detected in animal tissues.
Julien Barbier, Daniel Gillet
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Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack
Toxins, 2010 Ribosome-inactivating proteins (RIPs) are EC3.2.32.22 N-glycosidases that recognize a universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single adenine (A4324 in rat) and irreversibly blocking protein translation, leading ...
Maria Serena Fabbrini +3 more
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Suicide nanoplasmids coding for ribosome-inactivating proteins [PDF]
European Journal of Pharmaceutical Sciences, 2022 Conventional eukaryotic expression plasmids contain a DNA backbone that is dispensable for the cellular expression of the transgene. In order to reduce the vector size, minicircle DNA technology was introduced. A drawback of the minicircle technology are
Sonntag, A. +8 more
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Toxins, 2011 The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to the Sambucus genus, have the characteristic that although being even more active than ricin inhibiting protein synthesis in cell-free extracts, they lack the high ...
Pilar Jiménez +4 more
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Evolution of plant ribosome-inactivating proteins [PDF]
, 2010 This contribution presents an updated analysis of the evolution of ribosome-inactivating proteins (RIPs) in plants. All evidence suggests that an ancestor of modern seed plants developed the RIP domain at least 300 million years ago.
Van Damme, Els +3 more
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Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research [PDF]
Molecules, 2017 The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline research field, mostly because of their promising medical ...
Andrea Bolognesi +3 more
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Biophysical and Biochemical Assays for Screening Small Molecule Inhibitors Targeting Toxin–Ribosome Interactions [PDF]
ToxinsRibosome-inactivating proteins are a class of toxins that target eukaryotic ribosomes, inhibit protein synthesis, and ultimately induce cell death. Several of these toxins pose significant clinical and public health threats.
Eric J. Bryan +6 more
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Ribosome-inactivating proteins: progress and problems.
Cellular and Molecular Life Sciences, 2006 Ribosome-inactivating proteins (RIPs), mostly from plants, are enzymes which depurinate rRNA, thus inhibiting protein synthesis, and depurinate also other polynucleotide substrates.
BATTELLI, MARIA GIULIA, STIRPE, FIORENZO
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