Cell Proliferation, EarlyView.We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang +12 more
wiley +1 more source
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET [PDF]
, 2023 Dimitris C. Kanellis +14 more
openalex +1 more source
Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman +4 more
wiley +1 more source
RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis
Cell Death and Differentiation, 2021 Pavel Moudrý +4 more
semanticscholar +1 more source
Genetic risk factor identification for common epilepsies guided by integrative omics data analysis
Epilepsia, EarlyView.Abstract Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...
Ashwini Mushunuri +9 more
wiley +1 more source
The FEBS Journal, EarlyView.A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina +9 more
wiley +1 more source
Neuronal processes contain the essential components for the late steps of ribosome biogenesis. [PDF]
Proc Natl Acad Sci U S AFusco CM +11 more
europepmc +2 more sources
Meioc-Piwil1 Complexes Regulate Ribosome Biogenesis for the Differentiation of Germline Stem Cells
, 2022 Toshihiro Kawasaki +12 more
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The FEBS Journal, EarlyView.Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner +13 more
wiley +1 more source
The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging [PDF]
, 2021 Marianne Mercer +3 more
openalex +1 more source