Results 181 to 190 of about 144,255 (280)

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Ribosome biogenesis programs define a three-gene RBscore with prognostic relevance in bladder cancer. [PDF]

Front Immunol
Luo G, Wang W, Tai S, Yan L, Luo H, Chang Y, Yang L, Yan J, Zhou J, Liang C.   +9 more
europepmc   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Functional impact of the eIF6 N106S mutation on ribosome biogenesis in wild type and Shwachman-Diamond syndrome cells. [PDF]

Mol Med
Bertrand A, Page SL, Pirabakaran V, Kermasson L, Brunet E, Donadieu J, Gleizes PE, O'Donohue MF, Revy P.   +8 more
europepmc   +1 more source

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability. [PDF]

J Biol Chem
Xu K, Bianco S, Beauparlant CJ, Côté V, Herrmann L, Droit A, Downey M, Nourani A, Côté J.   +8 more
europepmc   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source

Wdr4 regulates ribosome biogenesis and intestinal homeostasis via let-7. [PDF]

EMBO Rep
Kajal K, Rastegari E, Wang WD, Li JC, Chen CH, Chou WH, Chang WC, Lin TY, Tsai K, Lu TM, Venkatachalam K, Hsu HJ.   +11 more
europepmc   +1 more source

Metabolic convergence on TOR signaling in the chestnut blight fungus and its regulation by host plant signals

New Phytologist, EarlyView.
Proposed model of metabolic convergence on the target of rapamycin (TOR) pathway in Cryphonectria parasitica. Twelve core genes involved in diverse metabolic pathways act as upstream regulators or downstream effectors of TOR kinase. Dysregulation of these genes mimics an inhibited TOR state, leading to restricted hyphal growth and enhanced trehalose ...
Yo‐Han Ko, Jeesun Chun, Geonmin Kim, Jiwon Yu, Dae‐Hyuk Kim   +4 more
wiley   +1 more source

Ribosome Biogenesis and Translational Control in Skeletal Muscle Atrophy and Hypertrophy: Mechanisms and Therapeutic Perspectives. [PDF]

Biomolecules
Xu M, Liu X.
europepmc   +1 more source