Results 181 to 190 of about 57,712 (282)

Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer. [PDF]

Nat Commun
Tanaka Y, Sakahara M, Yamanaka H, Natsume Y, Kusama D, Kumegawa K, Yoshikawa H, Abe Y, Okabayashi K, Matui S, Kitagawa Y, Koshikawa N, Osumi H, Shinozaki E, Nagayama S, Adachi J, Maruyama R, Yao R.   +17 more
europepmc   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

A liaison between mTOR signaling, ribosome biogenesis and cancer

The ability to translate genetic information into functional proteins is considered a landmark in evolution. Ribosomes have evolved to take on this responsibility and, although there are some differences in their molecular make-up, both prokaryotes and ...
Gentilella, Antonio, Thomas, George, Kozma, Sara C.   +2 more
core   +1 more source

TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K-S6RP proteins. [PDF]

Cell Mol Biol Lett
Stavropoulos A, Stamatopoulou V, Pavlos E, Manioudaki M, Sakellariou S, Stathopoulos C, Xilouri M.   +6 more
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Protocol to analyze steps of ribosome biogenesis in nuclear and cytosolic fractions of yeast cells. [PDF]

STAR Protoc
Zadali R, Topf U.
europepmc   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis. [PDF]

Commun Biol
Huttunen M, Hakanen S, Aho V, Leclerc S, Soenmez A, Kapishnikov S, Zannotti A, Ruokolainen V, Salokas K, Varjosalo M, Latonen L, Parrish CR, Fahy K, Mattola S, Lafontaine DLJ, Vihinen-Ranta M.   +15 more
europepmc   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, EarlyView.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source