Results 191 to 200 of about 142,894 (282)

Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis. [PDF]

Commun Biol
Huttunen M, Hakanen S, Aho V, Leclerc S, Soenmez A, Kapishnikov S, Zannotti A, Ruokolainen V, Salokas K, Varjosalo M, Latonen L, Parrish CR, Fahy K, Mattola S, Lafontaine DLJ, Vihinen-Ranta M.   +15 more
europepmc   +1 more source

Impact of 14 days of head‐down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults

Experimental Physiology, EarlyView.
Abstract Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults.
Jean‐Christophe Lagacé, Philippe St‐Martin, Mariano Avino, Ahmed Ghachem, Guy Hajj‐Boutros, Jose A. Morais, Jamie S. McPhee, Karen Lambert, Eléonor Riesco, Isabelle J. Dionne   +9 more
wiley   +1 more source

RNase MRP subunit composition and role in 40S ribosome biogenesis. [PDF]

Nat Struct Mol Biol
Smith EM, Ly J, Haug S, Cheeseman IM.
europepmc   +1 more source

Multi‐omics identifies promoter methylation and gene expression changes associated with human skeletal muscle atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle atrophy is a secondary complication in the aetiology of injury and chronic disease. Identifying mechanisms that control muscle mass is necessary to characterise atrophy and develop prevention strategies. We aimed to integrate transcriptomic and epigenomic data to identify key regulatory pathways controlled by promoter DNA ...
Jamie‐Lee M. Thompson, Thomas M. Doering, Boris P. Budiono, Kristen L. Mackenzie‐Shalders, Kevin J. Ashton, Paul J. Dunn, Vernon G. Coffey   +6 more
wiley   +1 more source

The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster. [PDF]

Proc Natl Acad Sci U S A
Duppe N, Knauer L, Hagebölling M, Langner L, Stümpfig M, Schünemann V, Pierik AJ, Netz DJ.   +7 more
europepmc   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Ribosome Biogenesis and Function in Cancer: From Mechanisms to Therapy. [PDF]

Cancers (Basel)
Gitareja K, Chelliah SS, Sanij E, Sandhu S, Kang J, Khot A.   +5 more
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

A high-throughput screen for nucleolar function reveals a role for the signaling protein, SPRR3, in ribosome biogenesis. [PDF]

J Biol Chem
Sutton EC, Bryant CJ, Gbenoba JIS, Lawrence IR, Baserga SJ.   +4 more
europepmc   +1 more source