Results 211 to 220 of about 142,894 (282)

Integrating Single-Cell, Bulk, and Spatial Transcriptomics Unveils a Novel Ribosome Biogenesis-Related Prognostic Model and Defines <i>RPS19BP1</i> as a Pro-Oncogenic Regulator in Lung Adenocarcinoma. [PDF]

Int J Mol Sci
Chen S, Du P, Luo Q, You S, Huang D, Ou Q, Zhang M, Chen L, Zhang D, Meng R.   +9 more
europepmc   +1 more source

Inhibition of METTL14 Alleviates OGD/R‐Induced Neuronal Differentiation Injury in Neural Stem Cells Through Suppressing the Tp53inp2/Ptgs2 Axis: Potential Benefits for the Mouse MCAO Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The graphical abstract highlights that ischemic stroke leads to increased METTL14 expression, which enhances Tp53inp2 mRNA stability through m6A modification. Elevated Tp53inp2 then promotes damaging mitophagy and ROS production by upregulating Ptgs2, ultimately impairing the neuronal differentiation of neural stem cells.
Dan Hou, Yujie Hu, Tian Yun, Dan Yu, Guoshuai Yang   +4 more
wiley   +1 more source

Establishment of an imaging-based screening pipeline for the identification of human ribosome biogenesis inhibitors. [PDF]

BMC Biol
Gafko C, Hollandi R, Dörner K, Rosellini M, Zemp I, Horvath P, Kutay U.   +6 more
europepmc   +1 more source

Paeonol Alleviate Cisplatin‐ and Noise‐Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Paeonol protects against cisplatin‐ and noise‐induced hearing loss by mitigating oxidative damage and preserving protein homeostasis in cochlear hair cells, revealing a novel mechanism involving ribosome biogenesis. ABSTRACT Background Hearing loss primarily results from irreversible cochlear hair cell (HC) damage caused by factors such as noise, aging,
Minhui Xia, Tianshi Sun, Wenyu Hou, Yiyun Lou, Yunjie Li, Hua Jiang, Hui Chai, Jiaoyao Ma, Mingyu Xia   +8 more
wiley   +1 more source

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates. [PDF]

Mol Cell
Akers JF, LaScola M, Bothe A, Suh H, Jung C, Stolp ZD, Ghosh T, Yan LL, Wang Y, Macurak M, Devan A, McKinney MC, Grismer TS, Reyes AV, Ross EJ, Hu T, Xu SL, Ban N, Kostova KK.   +18 more
europepmc   +1 more source

Evolutionary Reorganization of Transcriptomic Architecture Across a UVB Tolerance Gradient in Fish

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Environmental stress can drive adaptation through changes in transcriptomic organization. Across a UVB tolerance gradient in fish, adaptive responses were associated with increasingly coordinated and functionally specialized transcriptomic networks built upon a conserved functional background.
Camilo Valdivieso, Miguel Luis Allende
wiley   +1 more source

8-Me-PIQ Expands Cord Blood CD34⁺ Hematopoietic Stem and Progenitor Cells via Metabolic Suppression and Inhibition of Ribosome Biogenesis. [PDF]

Stem Cell Rev Rep
Li Y, Li M, Guo B, Jiang R.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Multi-omics integration identifies ribosome biogenesis-active macrophage subpopulation and its key gene GNL2 in driving liver hepatocellular carcinoma progression and mechanisms. [PDF]

Cancer Cell Int
Qi Y, Li K, Li P, Yan J, Feng S, Wan D, Du K, Liang X, Yang F, Zhou E, Huang N, Wang Q, Liu N.   +12 more
europepmc   +1 more source

Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi, Federica Martina Di Domenico, Gian Marco Leggio, Giuseppe Caruso, Evelyn Frias‐Toral, Nohora Milena Martínez López, Agnieszka Micek, Marialaura Bonaccio, Justyna Godos, Giuseppe Grosso   +9 more
wiley   +1 more source