Results 221 to 230 of about 57,712 (282)

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

Cancer Medicine, Volume 15, Issue 6, June 2026.
Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan, Fang Fang, Jing Sun, Yumeng Li, Yaochi Chen, Wanling Sun   +5 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Correction to 'The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Transcription factor 25 modulates gametocytogenesis and ribosome biogenesis in the malaria parasite <i>Plasmodium falciparum</i>. [PDF]

Front Cell Infect Microbiol
Wu J, Zhang Z, Ngim C, Yang W, Li P, Wang F, Ye J, Li B, Tian B, Zhang Q, Shang X.   +10 more
europepmc   +1 more source

A RiboCancer cell line panel reveals that CLL‐associated Rps15 mutations translationally rewire transcription through codon‐specific tRNA accommodation defects

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T‐cell acute lymphoblastic leukemia (T‐ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T‐ALL, multiple myeloma, and in a variety of ...
Anaïs Astier, Marino Caruso, Stijn Vereecke, Paulo E. Santo, Coralie Capron, Carine Froment, Dana Rinaldi, David Cabrerizo Granados, Marine Leclercq, Jonathan Royaert, Jelle Verbeeck, Naomy Pasau, Laura Plassart, Daniele Pepe, Steven Verbruggen, Hermes Paraqindes, Simon Lebaron, Virginie Marcel, Sébastien Durand, Clément Chapat, Gerben Menschaert, Pierre Close, Francesca Rapino, Frédéric Catez, Julien Marcoux, Célia Plisson‐Chastang, Kim De Keersmaecker   +26 more
wiley   +1 more source

Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex. [PDF]

Nat Commun
Wang W, Mahboubi A, Zhu S, Hanson J, Mateus A, Niittylä T.   +5 more
europepmc   +1 more source

FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia. [PDF]

Sci Adv
Li W, Zhao Y, Wu D, Chen Z, Qing Y, Yang F, Ji F, Zhang L, Sau L, Chen J, He C.   +10 more
europepmc   +1 more source

PTGER4 Governs Immune Evasion and Therapy Resistance in Kidney Cancer via Ribosome Biogenesis Dysregulation. [PDF]

J Cell Mol Med
Zhou H, Li Z, Ying J, Liu Y, Xu X, Huang J.   +5 more
europepmc   +1 more source

Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth. [PDF]

Mol Cancer Ther
Ahmad M, Alvi SS, Ahsan H, Perez C, Massey A, Kashyap VK, Chauhan N, Anning E, Tripathi MK, Kim DJ, Sahoo N, Oraby T, Yallapu MM, Khan MM, Sebastian MM, Chauhan SC, Hafeez BB.   +16 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source