Results 251 to 260 of about 173,360 (283)

Identification of polyphosphate-binding proteins in <i>Escherichia coli</i> uncovers targets involved in translation control and ribosome biogenesis. [PDF]

mBio
Baijal K, Kore B, Abramchuk I, Denoncourt A, Han S, Simms A, Dagenais A, Long AR, Rudner AD, Lavallée-Adam M, Gray MJ, Downey M.   +11 more
europepmc   +1 more source

De Novo Transcriptome Assembly Reveals Insights Into Osmoregulation and Oxidative Stress Response in the Gills of the Southern King Crab (Lithodes santolla)

Ecology and Evolution, Volume 15, Issue 11, November 2025.
The Southern King Crab (Lithodes santolla), an ecologically and commercially important species in sub‐Antarctic waters. In this study, we assembled the first gill de novo transcriptome of L. santolla to characterize gene expression related to environmental responses.
Alexandra Brante, Paulina Bustos, Claudio Ortega‐Muñoz, Eliana Paola Acuña Gómez, Vicenzo Brante, Rodolfo Farlora   +5 more
wiley   +1 more source

VesicleVoyager: In Vivo Selection of Surface Displayed Proteins That Direct Extracellular Vesicles to Tissue‐Specific Targets

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
ABSTRACT The development of technologies for screening proteins that bind to specific tissues in vivo and facilitate delivery of large cargos remains challenging, with most approaches limited to cell culture systems that often yield clinically irrelevant hits.
Yuki Kawai‐Harada, Mehrsa Mardikoraem, Ashley V. Makela, Katherine Lauro, Jeannie Lam, Christopher H. Contag, Daniel Woldring, Masako Harada   +7 more
wiley   +1 more source

An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation. [PDF]

Life Sci Alliance
Román-Trufero M, Kleijn IT, Blighe K, Zhou J, Saavedra-García P, Gaffar A, Christoforou M, Bellotti A, Abrahams J, Atrih A, Lamont D, Gierlinski M, Jayaprakash P, Michel AM, Aboagye EO, Yuneva M, Masson GR, Shahrezaei V, Auner HW.   +18 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy

MedComm, Volume 6, Issue 11, November 2025.
This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan, Wenlong Zhu, Yuan Chen, Wanwan Zhu, Jin Ding   +4 more
wiley   +1 more source

Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction. [PDF]

Cell Mol Gastroenterol Hepatol
Cho CJ, Nguyen T, Rougeau AK, Huang YZ, To S, Lin X, Thalalla Gamage S, Meier JL, Mills JC.   +8 more
europepmc   +1 more source

Supplementary Data S3 from BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma

Keiji Kurata, Mehmet K. Samur, Priscilla Liow, Kenneth Wen, Leona Yamamoto, Jiye Liu, Eugenio Morelli, Annamaria Gullà, Yu-Tzu Tai, Jun Qi, Teru Hideshima, Kenneth C. Anderson   +11 more
openalex   +1 more source

A New N6‐Methyladenosine Inhibitor, Celastrol, Alleviates Rheumatoid Arthritis via Targeting IGF2BP3

MedComm, Volume 6, Issue 11, November 2025.
CEL inhibited the IGF2BP3/RASGRF1/mTORC1 axis to reduce cell proliferation and inflammatory activation, thereby alleviating the progression of RA. ABSTRACT The proliferation of fibroblast‐like synoviocytes (FLS) and macrophage‐mediated inflammation are the main clinical features of rheumatoid arthritis (RA).
Qishun Geng, Yi Jiao, Wenya Diao, Jiahe Xu, Zhaoran Wang, Xing Wang, Zihan Wang, Lu Zhao, Lei Yang, Yilin Wang, Kan Wang, Tingting Deng, Bailiang Wang, Cheng Xiao   +13 more
wiley   +1 more source

Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer

The Journal of Pathology, Volume 267, Issue 3, Page 329-346, November 2025.
Abstract Multiplatform mutational and gene expression profiling complemented with proteomic and metabolomic spatial mapping were used on the whole‐organ scale to identify the molecular profile of bladder cancer evolution from field effects. Analysis of the mutational landscape identified three types of mutations, referred to as α, β, and γ.
Sangkyou Lee, Sung Yun Jung, Pawel Kuś, Jolanta Bondaruk, June Goo Lee, Roman Jaksik, Nagireddy Putluri, Khanh N Dinh, David Cogdell, Huiqin Chen, Yishan Wang, Jiansong Chen, Neema Navai, Colin Dinney, Cathy Mendelsohn, David McConkey, Richard R Behringer, Charles C Guo, Peng Wei, Marek Kimmel, Bogdan Czerniak   +20 more
wiley   +1 more source