MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Ricinus Agglutinin Induced Autophagy in Glioblastoma Cells [PDF]
, 2015 Ricinus agglutinin (RA) is a heterodimer consisting of two chains known as chain A and chain B respectively. The molecular weight of RA is 120 kD. RA is highly toxic to normal cells due to its ability to bind to the carbohydrate moieties present on the ...
Sahoo, puja
core
Synthetic biology—putting engineering into biology [PDF]
, 2006 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core +1 more source
Construction, Expression, and Characterization of BD1-G28-5 sFv, a Single-chain Anti-CD40 Immunotoxin Containing the Ribosome-inactivating Protein Bryodin 1 [PDF]
, 1997 Joseph A. Francisco +2 more
openalex +1 more source
Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins
BIO-PROTOCOL, 2017 Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No. 4324 from the 28S rRNA and its ribose in rat ribosomes (or the equivalent adenine in sensitive ribosomes from other organisms).
José Ferreras +2 more
openaire +4 more sources
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Influence of fluid dynamic conditions on 1,3-propanediol production from glycerol by Shimwellia blattae: Carbon flux and cell response [PDF]
, 2016 The fluid dynamic conditions play a key role in the development and scaling up of bioprocesses. In aerobic cultures, oxygen is an essential substrate for microbial growth, production and culture maintenance; an effective gas-liquid transfer must be ...
Alcon +46 more
core +1 more source
A complex fruit‐specific type‐2 ribosome‐inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants [PDF]
, 2002 Ying Chen +5 more
openalex +1 more source