Results 121 to 130 of about 25,873 (253)

Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases

Toxins, 2018
Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae, and bacteria. RIP activities have also been detected in animal tissues.
Julien Barbier, Daniel Gillet
doaj   +1 more source

Enhanced tolerance to bacterial pathogens caused by the transgenic expression of barley lipid transfer protein LTP2 [PDF]

, 1997
Purified lipid transfer protein LTP2 from barley applied on tobacco leaves eliminated symptoms caused by infiltration of Pseudomonas syringae pv. tabaci 153.
García Olmedo, Francisco, Molina Fernández, Antonio   +1 more
core   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation [PDF]

, 2017
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin.
Begley, Victoria Sarah, Chávez de Diego, Sebastián, Cruz Díaz, Jesús de la, Gómez Herreros, Fernando, Holstege, Frank C.P., Margaritis, Thanasis, Millán Zambrano, Gonzalo, Morillo Huesca, Macarena, Muñoz Centeno, María de la Cruz, Pelechano, Vicent, Pérez Ortín, José Enrique, Rodríguez Galán, Olga   +11 more
core   +3 more sources

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Lectinas vegetales: utilización en histoquímica y terapia antitumoral [PDF]

, 2016
Numerosas plantas expresan en su composición una o más lectinas o bien proteínas con un dominio lectina, permitiendo a éstas seleccionar y unirse a determinadas estructuras.
Velasco Martín, Felipe
core  

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Redundant and Flexible Electron Transfer Pathways Underlie MsrPQ‐Mediated Repair of Oxidized Periplasmic Proteins

Molecular Microbiology, EarlyView.
This study investigates in vivo the role of the flavin reductase Fre as an electron supplier to the periplasmic methionine sulfoxide reductase system MsrPQ. ABSTRACT The MsrPQ system is essential for the repair of oxidized methionine residues in periplasmic proteins, ensuring bacterial resistance to oxidative stress and envelope integrity.
Laurent Loiseau, Benjamin Ezraty
wiley   +1 more source

Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome-inactivating protein from shiitake mushroom (Lentinula edodes). [PDF]

Protein Sci, 2023
Citores L, Ragucci S, Russo R, Gay CC, Chambery A, Di Maro A, Iglesias R, Ferreras JM.   +7 more
europepmc   +1 more source