Results 51 to 60 of about 26,838 (281)

Dianthin and Its Potential in Targeted Tumor Therapies [PDF]

, 2019
Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Fuchs, Hendrik
core   +1 more source

Ricin trafficking in plant and mammalian cells [PDF]

, 2011
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core   +2 more sources

Novel Ribosome-inactivating Protein (RIP) Isolated from Trichosanthes dioica Induces Apoptosis in HeLa Cell Line

International Journal of Bio-Resource and Stress Management, 2021
Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate eukaryotic and prokaryotic rRNAs and thus interrupt protein synthesis during translation.
T. Ghosh, Y. Vashi, K. Barman, L. I. Singha   +3 more
doaj  

Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 [PDF]

, 2012
We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and its
Casero, David, Daniels Wells, Tracy R., Diamante, Graciel, Erb, Michael A., Helguera, Gustavo Fernando, Leoh, Lai Sum, Martinez Maza, Otoniel, Pellegrini, Mateo, Penichet, Manuel L., Rodríguez, José A.   +9 more
core   +2 more sources

Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation

Toxins, 2016
To improve the pharmacological properties of maize ribosome-inactivating protein (maize RIP) for targeting HIV-infected cells, the previously engineered TAT-fused active form of maize RIP (MOD) was further engineered for cysteine-directed PEGylation.
Ka-Yee Au, Wei-Wei Shi, Shuai Qian, Zhong Zuo, Pang-Chui Shaw   +4 more
doaj   +1 more source

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora, Baird, Beugnet, Boultwood, Brandenburger, Brenneisen, Browne, Chresta, Christopher G. Proud, Dong, Drygin, Dunlop, Feldman, Fonseca, Fonseca, Fumagalli, Gingras, Grimm, Hannan, Hara, Holzel, Horn, Horos, Huang, Iadevaia, Iadevaia, Jastrzebski, Jefferies, Julien Averous, Killian, Kimball, Kispal, Lam, Le-Bacquer, Lempiainen, Lempiainen, Loreni, Mayer, Mayer, Meyuhas, Miluzio, Montanaro, Oshiro, Patursky-Polischuk, Pearce, Pearson, Peter M. Taylor, Pianese, Popowski, Proud, Redpath, Rodnina, Rohrmoser, Rui Liu, Sancak, Sancak, Sanchez, Sarbassov, Smith, Strezoska, Strezoska, Thoreen, Valentina Iadevaia, Wang, Wang, Willett, Xiao, Yip, Ze Zhang   +68 more
core   +6 more sources

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Involvement of loops 2 and 3 of alpha-sarcin on its ribotoxic activity [PDF]

, 2015
Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with a-sarcin as its best-characterized member.
Castaño Rodríguez, Carlos, García Ortega, Lucía, Gavilanes, José G., Lacadena García-Gallo, Javier, Martínez del Pozo, Álvaro, Olombrada Sacristán, Miriam, Oñaderra Sánchez, Mercedes, Partida Hanon, Angélica   +7 more
core   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage

Frontiers in Microbiology, 2023
IntroductionBacteria must combat phages, and myriad bacterial anti-phage systems have been discovered that reduce host metabolism, for example, by depleting energetic compounds like ATP and NAD+. Hence, these systems indirectly inhibit protein production.
Laura Fernández-García, Laura Fernández-García, María Tomás, Thomas K. Wood   +3 more
doaj   +1 more source