Results 201 to 210 of about 21,394 (229)

BIOACTIVITIES OF SoRIP1, A TYPE 1 RIBOSOME INACTIVATING PROTEIN FROM SPINACIA OLERACEA

Abstract A single-stranded ribosome inactivating protein SoRIP1 from Spinacia oleracea (Spinach) is a 30 kDa protein. It is a multipurpose protein with versatile biological activities. This paper defines cloning and expression of SoRIP1 in bacteria to study its versatile biological properties and cytotoxic potential.
PAKEEZA ISMAIL, Dr. ALEENA SUMRIN
openaire   +1 more source

A Simplified Procedure for the Purification of Trichosanthin (A Type 1 Ribosome Inactivating Protein) fromTrichosanthes kirilowiiRoot Tubers

Protein Expression and Purification, 1996
A one step rapid and simple purification procedure for trichosanthin, a type 1 ribosome inactivating protein, from root tubers of Trichosanthes kirilowii has been developed using cation-exchange perfusion chromatography. The identity of the protein has been confirmed by its size, immunoreactivity, and sequence information.
N, Bhatia, K A, McDonald, A P, Jackman, A M, Dandekar   +3 more
openaire   +2 more sources

Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
The ribosome inactivating proteins (RIPs) of type 1 are plant toxins that eliminate adenine base selectively from the single stranded loop of rRNA. We report six crystal structures, type 1 RIP from Momordica balsamina (A), three in complexed states with ribose (B), guanine (C) and adenine (D) and two structures of MbRIP-1 when crystallized with ...
Gajraj Singh, Kushwaha, Nisha, Pandey, Mau, Sinha, S Baskar, Singh, Punit, Kaur, Sujata, Sharma, Tej P, Singh   +6 more
openaire   +2 more sources

In vitro anti‐tumour activity of anti‐CD80 and anti‐CD86 immunotoxins containing type 1 ribosome‐inactivating proteins

British Journal of Haematology, 2000
Immunotoxins specific for the CD80 and CD86 antigens were prepared by linking three type 1 ribosome‐inactivating proteins (RIPs), namely bouganin, gelonin and saporin‐S6, to the monoclonal antibodies M24 (anti‐CD80) and 1G10 (anti‐CD86). These immunotoxins showed a specific cytotoxicity for the CD80/CD86‐expressing cell lines Raji and L428.
Bolognesi A., Polito L., Tazzari P. L., Lemoli R. M., Lubelli C., Fogli M., Boon L., De Boer M., Stirpe F.   +8 more
openaire   +3 more sources

Enhanced cytotoxic activity of a bifunctional chimeric protein containing a type 1 ribosome-inactivating protein and a serine protease inhibitor

Biochimie, 2012
Both ribosome-inactivating proteins (RIPs) and plant proteinase inhibitors, belong to protein families known to regulate cellular homeostasis and likely involved in plant defense. Nevertheless the interest in these protein classes is due to their potential use for the treatment of several important human diseases such as cancer.
Rachele Tamburino, PIZZO, ELIODORO, SARCINELLI, CARMEN, Elia Poerio, Francesca Tedeschi, Anna G. Ficca, Augusto Parente, Antimo Di Maro   +7 more
openaire   +5 more sources

Purification and Conjugation of Type 1 Ribosome-Inactivating Proteins

2003
L, Barbieri, A, Bolognesi, F, Stirpe
openaire   +2 more sources

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

Nature Reviews Drug Discovery, 2023
P V Kolkhir, Thomas Bieber, E Guttman-Yassky   +2 more
exaly  

Type VII secretion systems: structure, functions and transport models

Nature Reviews Microbiology, 2021
Angel Rivera-Calzada, Nikolaos Famelis, Oscar Llorca   +2 more
exaly  

Targeting inflammation in the treatment of type 2 diabetes: time to start

Nature Reviews Drug Discovery, 2014
Marc Y Donath
exaly  

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

Nature Reviews Drug Discovery, 2011
Frank D Waldron-Lynch, Kevan C Herold
exaly