Results 31 to 40 of about 30,415 (253)

X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein [PDF]

BMC Structural Biology, 2007
Abstract Background Protein sequence can be obtained through Edman degradation, mass spectrometry, or cDNA sequencing. High resolution X-ray crystallography can also be used to derive protein sequence information, but faces the difficulty in distinguishing the Asp/Asn, Glu/Gln, and Val/Thr pairs. Luffaculin 1 is a new
Hou, Xiaomin, Chen, Minghuang, Chen, Liqing, Meehan, Edward J, Xie, Jieming, Huang, Mingdong   +5 more
openaire   +2 more sources

Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site [PDF]

, 2007
Maize ribosome-inactivating protein is classified as a class III or an atypical RNA N-glycosidase. It is synthesized as an inactive precursor with a 25-amino acid internal inactivation region, which is removed in the active form.
Amanda Nga-Sze Mak, Bang, Bass, Bass, Cavallaro, Chan, Chan, Chan, Chan, Cheung, Di, Dowd, Girbes, Hartley, Hess, Hey, Hudak, Kam-Bo Wong, Kim, Kong-Hung Sze, Krawetz, Laskowski, Motto, Pang-Chui Shaw, Parikh, Ragulina, Rajamohan, Robertus, Savino, Schnell, Shannon Wing-Ngor Au, Shaw, Spedding, Stirpe, Sun-Shin Cha, Vater, Walsh, Wong, Young-Jun An, Yuen-Ting Wong, Zheng   +40 more
core   +2 more sources

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein [PDF]

Toxins, 2018
Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA). TCS has only one chain, and is classified as type 1 ribosome-inactivating protein (RIP). Our structural studies revealed that TCS consists of two domains, with five conserved catalytic residues Tyr70 ...
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
openaire   +3 more sources

Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy

Toxins, 2011
Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death.
Andrea Bolognesi, Massimo Bortolotti, Manuela Pedrazzi, Letizia Polito   +3 more
doaj   +1 more source

MAPK Cascade Signaling Is Involved in α-MMC Induced Growth Inhibition of Multiple Myeloma MM.1S Cells via G2 Arrest and Mitochondrial-Pathway-Dependent Apoptosis In Vitro

Pharmaceuticals, 2023
Multiple myeloma is a hematological malignancy characterized by the unrestricted proliferation of plasma cells that secrete monoclonal immunoglobulins in the bone marrow.
Zi-Wei Cai, Ting Ye, Pei-Wen Jiang, Yu-Jiao Liao, Lin Wang, Qing-Liang Zhang, Wen-Qian Du, Min Huang, Ping Yang, Min-Hui Li   +9 more
doaj   +1 more source

Impact of Mistletoe Triterpene Acids on the Uptake of Mistletoe Lectin by Cultured Tumor Cells. [PDF]

PLoS ONE, 2016
Complementary treatment possibilities for the therapy of cancer are increasing in demand due to the severe side effects of the standard cytostatics used in the first-line therapy.
Katharina Mulsow, Thomas Enzlein, Catharina Delebinski, Sebastian Jaeger, Georg Seifert, Matthias F Melzig   +5 more
doaj   +1 more source

Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]

, 2015
Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli, Adigbli, Arentsen, Baglo, Berg, Berg, Berg, Berg, Berstad, Bodles-Brakhop, Bostad, Bostad, Bull-Hansen, Castano, Castano, Chong, Dietze, Dietze, Elisabeth Olsen, Fretz, Gaware, Gooding, Gottesman, Hirschberg, Høgset, Jørgensen, Kunz, Lai, Lai, Lakshmanan, Lou, Lu, Lund, Mathews, Mroz, Mroz, Norum, Norum, Norum, Norum, Pasparakis, Peng, Peng, Prasmickaite, Reginato, Rosenblum, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, St Denis, Stratford, Todorova, Vikdal, Wang, Wang, Wang, Weyergang, Weyergang, Woodhams, Xu, Yaghini, Yao, Yip, Zahreddine   +69 more
core   +1 more source

Recombinant anti-HIV MAP30, a ribosome inactivating protein: against plant virus and bacteriophage

Scientific Reports, 2023
The ribosome inactivating proteins (RIPs) efficiently decrease the microbial infections in plants. Momordica charantia MAP30 is a type I RIP that has not been investigated against plant viruses or bacteriophages.
Nafiseh Amirzadeh, Ali Moghadam, Ali Niazi, Alireza Afsharifar   +3 more
doaj   +1 more source

Glycotope structures and intramolecular affinity factors of plant lectins for Tn/T antigens [PDF]

, 2011
B
A Babino, AA Jeyaprakash, AM Wu, AM Wu, AM Wu, AM Wu, AM Wu, AM Wu, AM Wu, AM Wu, E Zenteno, EJM Damme Van, GF Springer, GF Springer, GF Springer, GWG Bird, K Puri, KA Kulkarni, KA Kulkarni, M Duk, M Duk, M Sarkar, N Taniguchi, N Vega, R Lotan, R Ravishankar, R Sankaranarayanan, R Zenteno, S Hirohashi, S Tollefsen, SH Itzkowitz, SI Hakomori, SI Hakomori, SI Hakomori, SJ Rinderle, T Singh, T Singh, T Singh, TR Transue, V Piller, W Wang, X Lee, Y Yoda   +42 more
core   +3 more sources

The Pharmacological Potential of Mushrooms [PDF]

, 2005
This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor, antiallergic, immunomodulating, anti-inflammatory, antiatherogenic, hypoglycemic, hepatoprotective and ...
Jülich, Wolf-Dieter, Lindequist, Ulrike, Niedermeyer, Timo H. J.   +2 more
core   +3 more sources