Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins [PDF]
Bio-Protocol, 2017 Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras +2 more
doaj +2 more sources
The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks [PDF]
Frontiers in Plant Science, 2018 Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate eukaryotic and prokaryotic rRNAs, thereby arresting protein synthesis during translation. RIPs are widely found in various plant species and within different tissues.
Feng Zhu +3 more
doaj +2 more sources
Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack [PDF]
Toxins, 2010 Ribosome-inactivating proteins (RIPs) are EC3.2.32.22 N-glycosidases that recognize a universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single adenine (A4324 in rat) and irreversibly blocking protein translation, leading ...
Maria Serena Fabbrini +3 more
doaj +2 more sources
Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions) [PDF]
Toxins, 2017 Plant ribosome-inactivating protein (RIP) toxins are EC3.2.2.22 N-glycosidases, found among most plant species encoded as small gene families, distributed in several tissues being endowed with defensive functions against fungal or viral infections.
Maria Serena Fabbrini +3 more
doaj +2 more sources
Structure and Biological Properties of Ribosome-Inactivating Proteins and Lectins from Elder (Sambucus nigra L.) Leaves. [PDF]
Toxins (Basel), 2022 Iglesias R +8 more
europepmc +3 more sources
Hyperuricaemia, Xanthine Oxidoreductase and Ribosome‐Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research [PDF]
Molecules, 2017 The enzymes called ribosome‐inactivating proteins (RIPs) that are able to depurinate nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline research field, mostly because of their promising medical ...
Andrea Bolognesi +3 more
doaj +2 more sources
Crystallization and preliminary X-ray studies of snake gourd lectin: homology with type II ribosome-inactivating proteins [PDF]
, 2001 Arulanandam, Jeyaprakash +6 more
core +2 more sources
Analysis of castor bean ribosome-inactivating proteins and their gene expression during seed development [PDF]
Genetics and Molecular Biology, 2013 Ribosome-inactivating proteins (RIPs) are enzymes that inhibit protein synthesis after depurination of a specific adenine in rRNA. The RIP family members are classified as type I RIPs that contain an RNA-N-glycosidase domain and type II RIPs that contain
Guilherme Loss-Morais +7 more
doaj +2 more sources
Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins. [PDF]
Sci Rep, 2012 Park JG, Kahn JN, Tumer NE, Pang YP.
europepmc +3 more sources
Ribosome-inactivating proteins: potent poisons and molecular tools. [PDF]
Virulence, 2013 Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of atomic structures and molecular mechanism has revealed these proteins to be a diverse group subdivided into two classes.
Walsh MJ, Dodd JE, Hautbergue GM.
europepmc +4 more sources