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Analysis of codon-specific translation by ribosome profiling
2021Chemical modifications of RNA molecules can affect translation in multiple ways. Therefore, it is critical to understand how their absence changes cellular translation dynamics and in particular codon-specific translation. In this chapter, we discuss the application of ribosome profiling to analyze changes in codon-specific translation and differential
Yeji, Kim +5 more
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Codon Resolution Analysis of Ribosome Profiling Data
2021Translation is a central biological process in living cells. Ribosome profiling approach enables assessing translation on a global, cell-wide level. Extracting versatile information from the ribosome profiling data usually requires specialized expertise for handling the sequencing data that is not available to the broad community of experimentalists ...
Bartholomäus, A., Ignatova, Z.
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Ribosome Profiling for Novel Antigen Discovery
The identification of targetable antigens is crucial for advancing cancer immunotherapy. While traditional methods focus on tumor-associated antigens and somatic variants, recent advancements have highlighted novel antigen classes such as splice isoforms, gene fusions, ribonucleic acid (RNA) editing, and novel or unannotated open reading frames (nuORFs)Ana, Xavier-Magalhães, Susan, Klaeger
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Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control
Molecular Cell, 2020Nicholas R Guydosh, Sezen Meydan
exaly
Identifying Small Open Reading Frames in Prokaryotes with Ribosome Profiling
Journal of Bacteriology, 2022Cynthia Mira Sharma +2 more
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Ribosome profiling reveals the what, when, where and how of protein synthesis
Nature Reviews Molecular Cell Biology, 2015Gloria Brar, Jonathan Weissman
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