Results 141 to 150 of about 105,196 (322)

Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization [PDF]

open access: yesJ. Mol. Biol. 382, 236-245 (2008), 2008
Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By modelling the stochastic translation process as a traffic problem, we here analyze conditions and ...
arxiv  

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

open access: yesAdvanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan   +13 more
wiley   +1 more source

Application of an Escherichia coli triple reporter strain for at‐line monitoring of single‐cell physiology during L‐phenylalanine production

open access: yesEngineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023
Abstract Biotechnological production processes are sustainable approaches for the production of biobased components such as amino acids for food and feed industry. Scale‐up from ideal lab‐scale bioreactors to large‐scale processes is often accompanied by loss in productivity.
Manh Dat Hoang   +5 more
wiley   +1 more source

Aqueous Two‐Phase Submicron Droplets Catalyze DNA Nanostructure Assembly for Confined Fluorescent Biosensing

open access: yesAdvanced Science, EarlyView.
Submicron droplets, formed by a polyethyleneglycol (PEG)/dextran aqueous two‐phase system·(ATPS), can act as catalytic centers that concentrate DNA and accelerate assembly kinetic in crowded environments. It highlights a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides ...
Xiaoman Duan   +5 more
wiley   +1 more source

It’s a competitive business

open access: yeseLife
A new in vitro system called Rec-Seq sheds light on how mRNA molecules compete for the machinery that translates their genetic sequence into proteins.
Masaaki Sokabe, Christopher S Fraser
doaj   +1 more source

Biomineralization‐Inspired Membranization Toward Structural Enhancement of Coacervate Community

open access: yesAdvanced Science, EarlyView.
The spontaneous formation of a mineralized membrane on the surface of coacervate droplets is facilitated by Fe3+ ions and redox reaction, accompanied by the aggregation of the coacervate droplets. These membranized coacervate assemblages not only retain the capacity for biomolecule sequestration and enzyme catalysis but also exhibit enhanced structural
Chunyu Zhao   +6 more
wiley   +1 more source

Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate

open access: yeseLife
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals that ...
Mina O Seedhom   +10 more
doaj   +1 more source

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