Results 161 to 170 of about 105,300 (304)

Studies on structural stability of thermophilic Sulfolobus acidocaldarius ribosomes

, 2007
19-25Structural stability of thermophilic archaeon Sulfolobus acidocaldarius ribosomes, with respect their susceptibility to pancreatic RNase A and stability to temperature (ΔTm), on treatment with various stabilizing (polyamines) and destabilizing ...
Suryanarayana, Tangirala, Yangala, Kalavathi   +1 more
core  

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Ribosomes of Acetabularia mediterranea

, 1969
1. 1. Whole homogenates of [3H]uridine-labelled Acetabularia mediterranea contain two major species of radioactive ribosomal particles, sedimenting at approx. 50 and 30 S. These particles contain, respectively, high and low molecular weight ribosomal RNA
Presburg, Monique, Janowski, Michel, Bonotto, Silvano   +2 more
core  

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Decoding cancer-associated ribosomal protein mutations: A new frontier in cancer and ribosome biology. [PDF]

Hemasphere
Čaušević M, Loewith R, Volarević S.
europepmc   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Ribosome stalling position, spacing, and A-site occupancy impact translation and cotranslational mRNA decay in plants. [PDF]

Proc Natl Acad Sci U S A
van der Horst S, Gage JL, Bailey-Serres J.   +2 more
europepmc   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center. [PDF]

Commun Biol
Schwaller N, Andenmatten D, Luginbühl J, Rabl J, Baur H, Chambon M, Vesin J, Turcatti G, Karousis ED.   +8 more
europepmc   +1 more source

Mitochondrial ribosomes [PDF]

FEBS Letters, 1971
Borst, P., Grivell, L.A.
openaire   +2 more sources